Sodium ion apparent diffusion coefficient in living rat brain

James A. Goodman, Christopher (Chris) Kroenke, G. Larry Bretthorst, Joseph J H Ackerman, Jeffrey J. Neil

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The apparent diffusion coefficient (ADC) of Na+ was determined in live rat brain. The brain extracellular-to-intracellular Na+ content ratio is ∼8:2, which is the inverse of that for water in these spaces. Consequently, the ADC of Na+ is primarily affected by motion in the extracellular space, and Na+ can be viewed as a reporter molecule for motion in that space. Likewise, water ADC is dominated by intracellular motion. The brain Na+ ADC was 1.15 ± 0.09 μm2/ms, which is 61% of the aqueous Na+ free diffusion coefficient (Dfree) at 37°C (1.9 μm2/ms), while the ADC for brain water is 28% of the water Dfree at 37°C (3 μm2/ms). This suggests that the ADC of molecular species within the extracellular space is roughly twofold that within the intracellular space. In postmortem brain, both Na+ and water decrease to 17% of the respective Dfree values. These results are consistent with Na + and water ADC values sharing the same biophysical determinants in postmortem brain. The observed difference between Na+ and water ADC/Dfree ratios in living brain tissue may be attributable to the extracellular environment hindering molecular displacements twofold less than the intracellular environment.

Original languageEnglish (US)
Pages (from-to)1040-1045
Number of pages6
JournalMagnetic Resonance in Medicine
Volume53
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Sodium
Ions
Brain
Water
Extracellular Space
Intracellular Space

Keywords

  • Brain
  • Compartmental diffusion
  • In vivo MRS
  • Na NMR
  • Sodium diffusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Goodman, J. A., Kroenke, C. C., Larry Bretthorst, G., Ackerman, J. J. H., & Neil, J. J. (2005). Sodium ion apparent diffusion coefficient in living rat brain. Magnetic Resonance in Medicine, 53(5), 1040-1045. https://doi.org/10.1002/mrm.20444

Sodium ion apparent diffusion coefficient in living rat brain. / Goodman, James A.; Kroenke, Christopher (Chris); Larry Bretthorst, G.; Ackerman, Joseph J H; Neil, Jeffrey J.

In: Magnetic Resonance in Medicine, Vol. 53, No. 5, 05.2005, p. 1040-1045.

Research output: Contribution to journalArticle

Goodman, JA, Kroenke, CC, Larry Bretthorst, G, Ackerman, JJH & Neil, JJ 2005, 'Sodium ion apparent diffusion coefficient in living rat brain', Magnetic Resonance in Medicine, vol. 53, no. 5, pp. 1040-1045. https://doi.org/10.1002/mrm.20444
Goodman, James A. ; Kroenke, Christopher (Chris) ; Larry Bretthorst, G. ; Ackerman, Joseph J H ; Neil, Jeffrey J. / Sodium ion apparent diffusion coefficient in living rat brain. In: Magnetic Resonance in Medicine. 2005 ; Vol. 53, No. 5. pp. 1040-1045.
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