Sodium intake, angiotensin II receptor blockade, and baroreflex function in conscious rats

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The hypothesis that endogenous angiotensin II (Ang II) chronically supports baroreflex control of lumbar sympathetic nerve activity (LSNA) and heart rate (HR) via AT1 but not AT2 receptors was tested in conscious, normotensive rats. Rats were fed either a sodium deficient diet (LS) to increase circulating Ang II or a high-sodium diet (HS) for 2 to 3 weeks. One to two days after surgery to implant catheters and nerve electrodes, baroreflex curves were produced before and 40 minutes after intravenous administration of the AT1 antagonist losartan (10 mg/kg) or the AT2 antagonist PD123319 (500 μg/kg+50 μg · kg-1 · min-1). Mean arterial pressure (MAP) after losartan was maintained at basal levels with methoxamine. Forty minutes after losartan in LS rats. LSNA (46±5 to 22±1% max) and HR (414±7 to 387±8 bpm) were decreased (P

Original languageEnglish (US)
Pages (from-to)450-457
Number of pages8
JournalHypertension
Volume29
Issue number1 II
StatePublished - Jan 1997

Fingerprint

Angiotensin Receptors
Losartan
Baroreflex
Sodium
Angiotensin II
Heart Rate
Diet
Methoxamine
Ambulatory Surgical Procedures
Intravenous Administration
Arterial Pressure
Electrodes
Catheters

Keywords

  • AT1
  • AT2
  • baroreflex
  • heart rate
  • losartan
  • lumbar sympathetic nerve activity
  • PD123319
  • sodium-deprived rats

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Sodium intake, angiotensin II receptor blockade, and baroreflex function in conscious rats. / Xu, Ling; Brooks, Virginia.

In: Hypertension, Vol. 29, No. 1 II, 01.1997, p. 450-457.

Research output: Contribution to journalArticle

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