TY - JOUR
T1 - Sleep Disturbances in TBI and PTSD and Potential Risk of Neurodegeneration
AU - Weymann, Kris B.
AU - Lim, Miranda M.
N1 - Funding Information:
This material is the result of work supported with resources and the use of facilities at the VA Portland Health Care System, the VA Office of Academic Affiliations Nursing Postdoctoral Research Fellowship (KBW), VA Career Development Award # IK2 BX002712, NIH EXITO Institutional Core, #UL1GM118964, and Portland VA Research Foundation (MML). The contents do not represent the views of the U.S. Department of Veterans Affairs or the U.S. Government. The authors would like to thank Dr. Jonathan E. Elliott for his helpful comments in the writing of this manuscript. This article is part of the Topical Collection on Sleep and Neurodegenerative Disorders Kris B. Weymann and Miranda M. Lim each declare no potential conflicts of interest.
Publisher Copyright:
© 2017, Springer International Publishing AG (outside the USA).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Purpose of Review: The purpose of this article is to present (1) a scoping review of recent evidence demonstrating the association of traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) with sleep disturbances and neurodegeneration, and (2) a more focused, systematic review of the association between TBI, PTSD, and obstructive sleep apnea (OSA), adherence to PAP therapy, and cognitive outcomes. Recent Findings: TBI and PTSD are strongly associated with sleep disruption. Multiple convergent lines of evidence indicate that sleep disruption, including in those with OSA, is a risk factor for neurodegeneration. TBI and PTSD have also been independently associated with neurodegeneration. Positive airway pressure (PAP) treatment of OSA in TBI and PTSD is effective but can be challenging. Untreated OSA is associated with impaired cognitive outcomes in this population. Summary: TBI and PTSD are both common neuropsychiatric illnesses associated with sleep disturbances and subsequent neurodegeneration, and are often comorbid conditions. Adequate treatment of OSA and other sleep disturbances in TBI and PTSD may be critical to mitigating the risk of neurodegeneration in these patients.
AB - Purpose of Review: The purpose of this article is to present (1) a scoping review of recent evidence demonstrating the association of traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) with sleep disturbances and neurodegeneration, and (2) a more focused, systematic review of the association between TBI, PTSD, and obstructive sleep apnea (OSA), adherence to PAP therapy, and cognitive outcomes. Recent Findings: TBI and PTSD are strongly associated with sleep disruption. Multiple convergent lines of evidence indicate that sleep disruption, including in those with OSA, is a risk factor for neurodegeneration. TBI and PTSD have also been independently associated with neurodegeneration. Positive airway pressure (PAP) treatment of OSA in TBI and PTSD is effective but can be challenging. Untreated OSA is associated with impaired cognitive outcomes in this population. Summary: TBI and PTSD are both common neuropsychiatric illnesses associated with sleep disturbances and subsequent neurodegeneration, and are often comorbid conditions. Adequate treatment of OSA and other sleep disturbances in TBI and PTSD may be critical to mitigating the risk of neurodegeneration in these patients.
KW - Neurodegeneration
KW - Obstructive sleep apnea
KW - Positive airway pressure
KW - Post-traumatic stress disorder
KW - Sleep
KW - Traumatic brain injury
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U2 - 10.1007/s40675-017-0077-0
DO - 10.1007/s40675-017-0077-0
M3 - Review article
AN - SCOPUS:85056639663
VL - 3
SP - 179
EP - 192
JO - Current Sleep Medicine Reports
JF - Current Sleep Medicine Reports
SN - 2198-6401
IS - 3
ER -