Skin perfusion assessed by contrast ultrasound predicts tissue survival in a free flap model

Jonathan P. Christiansen, Howard Leong-Poi, Lester R. Amiss, David B. Drake, Sanjiv Kaul, Jonathan R. Lindner

    Research output: Contribution to journalArticle

    18 Scopus citations

    Abstract

    The purpose of this study was to assess perfusion in a free skin flap model using contrast-enhanced ultrasound (CEU), and to determine if the extent of perfusion early after venous occlusion predicted long-term flap survival. Perfusion was assessed in an autologous abdominal skin flap and adjacent healthy skin in rats using CEU imaging before venous occlusion and following reflow. Perfusion assessment was possible in all flaps and quantitative measurements of microvascular blood volume (BV) and blood velocity were expressed as a ratio to that in the healthy skin. Proximal flap BV 18 h after venous occlusion was significantly greater in those that survived (n = 4) vs. those that became necrotic (n = 6) (BV ratio 0.8 ± 0.1 vs. 0.2 ± 0.1, p = 0.0001). A BV ratio of 0.5 predicted graft viability with a sensitivity and specificity of 100%. Microvascular blood velocity at 18 h was similar in grafts that survived and those that became necrotic. Qualitative assessment of perfusion by a 'blinded' observer correlated well with quantitative data and predicted flap outcome in all cases. We conclude that skin perfusion can be assessed with CEU. Perfusion 18 h following a secondary ischemic insult in a free flap accurately predicts subsequent tissue survival in this model.

    Original languageEnglish (US)
    Pages (from-to)315-320
    Number of pages6
    JournalUltrasound in Medicine and Biology
    Volume28
    Issue number3
    DOIs
    StatePublished - Jan 1 2002

    Keywords

    • Contrast
    • Flap
    • Perfusion
    • Skin
    • Ultrasound

    ASJC Scopus subject areas

    • Biophysics
    • Radiological and Ultrasound Technology
    • Acoustics and Ultrasonics

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