Abstract
Background.-Botulinum toxin may be effective in suppressing migraine. Most injection regimens utilized have involved multiple sites. Purpose.-To evaluate prospectively the effect of botulinum toxin type A injections into the corrugator supercilii muscles alone on the frequency and severity of migraine. Methods.-Twenty-nine patients (24 women, 5 men) with migraine were enrolled in the study. Average age was 45 years (range, 24 to 63). The frequency (number of migraines per month) and intensity (recorded on an analog scale of 1 to 10, 10 being most severe) of headache were recorded before and after treatment. Twenty-five units of botulinum toxin type A was injected into each corrugator supercilii muscle, for a total of 50 units. Results.-At 2 months, 24 (83%) of 29 patients reported a positive response to the injection of botulinum toxin type A (P <.001). Sixteen patients (55%) reported complete elimination of headache (P <.001), 8 (28%) experienced significant improvement (at least 50% reduction in frequency or intensity) (P <.04), and 5 (17%) did not notice a change in headache. The duration of efficacy of the botulinum toxin type A injections ranged from 6 to 12 weeks, with an average of 8 weeks. In patients who had improvement in migraine but not complete elimination, the headache frequency decreased from 6.4 to 2.1 per month on average (P <.04), and the intensity decreased from 8.6 to 6.1 (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1085-1089 |
| Number of pages | 5 |
| Journal | Headache |
| Volume | 43 |
| Issue number | 10 |
| DOIs | |
| State | Published - Nov 2003 |
| Externally published | Yes |
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Keywords
- Botulinum toxin type A
- Corrugator supercilii muscle
- Migraine
- Trigger point
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Single-Site Botulinum Toxin Type A Injection for Elimination of Migraine Trigger Points. / Behmand, Ramin A.; Tucker, Tarvez; Guyuron, Bahman.
In: Headache, Vol. 43, No. 10, 11.2003, p. 1085-1089.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single-Site Botulinum Toxin Type A Injection for Elimination of Migraine Trigger Points
AU - Behmand, Ramin A.
AU - Tucker, Tarvez
AU - Guyuron, Bahman
PY - 2003/11
Y1 - 2003/11
N2 - Background.-Botulinum toxin may be effective in suppressing migraine. Most injection regimens utilized have involved multiple sites. Purpose.-To evaluate prospectively the effect of botulinum toxin type A injections into the corrugator supercilii muscles alone on the frequency and severity of migraine. Methods.-Twenty-nine patients (24 women, 5 men) with migraine were enrolled in the study. Average age was 45 years (range, 24 to 63). The frequency (number of migraines per month) and intensity (recorded on an analog scale of 1 to 10, 10 being most severe) of headache were recorded before and after treatment. Twenty-five units of botulinum toxin type A was injected into each corrugator supercilii muscle, for a total of 50 units. Results.-At 2 months, 24 (83%) of 29 patients reported a positive response to the injection of botulinum toxin type A (P <.001). Sixteen patients (55%) reported complete elimination of headache (P <.001), 8 (28%) experienced significant improvement (at least 50% reduction in frequency or intensity) (P <.04), and 5 (17%) did not notice a change in headache. The duration of efficacy of the botulinum toxin type A injections ranged from 6 to 12 weeks, with an average of 8 weeks. In patients who had improvement in migraine but not complete elimination, the headache frequency decreased from 6.4 to 2.1 per month on average (P <.04), and the intensity decreased from 8.6 to 6.1 (P
AB - Background.-Botulinum toxin may be effective in suppressing migraine. Most injection regimens utilized have involved multiple sites. Purpose.-To evaluate prospectively the effect of botulinum toxin type A injections into the corrugator supercilii muscles alone on the frequency and severity of migraine. Methods.-Twenty-nine patients (24 women, 5 men) with migraine were enrolled in the study. Average age was 45 years (range, 24 to 63). The frequency (number of migraines per month) and intensity (recorded on an analog scale of 1 to 10, 10 being most severe) of headache were recorded before and after treatment. Twenty-five units of botulinum toxin type A was injected into each corrugator supercilii muscle, for a total of 50 units. Results.-At 2 months, 24 (83%) of 29 patients reported a positive response to the injection of botulinum toxin type A (P <.001). Sixteen patients (55%) reported complete elimination of headache (P <.001), 8 (28%) experienced significant improvement (at least 50% reduction in frequency or intensity) (P <.04), and 5 (17%) did not notice a change in headache. The duration of efficacy of the botulinum toxin type A injections ranged from 6 to 12 weeks, with an average of 8 weeks. In patients who had improvement in migraine but not complete elimination, the headache frequency decreased from 6.4 to 2.1 per month on average (P <.04), and the intensity decreased from 8.6 to 6.1 (P
KW - Botulinum toxin type A
KW - Corrugator supercilii muscle
KW - Migraine
KW - Trigger point
UR - http://www.scopus.com/inward/record.url?scp=0347381129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0347381129&partnerID=8YFLogxK
U2 - 10.1046/j.1526-4610.2003.03210.x
DO - 10.1046/j.1526-4610.2003.03210.x
M3 - Article
C2 - 14629244
AN - SCOPUS:0347381129
VL - 43
SP - 1085
EP - 1089
JO - Headache
JF - Headache
SN - 0017-8748
IS - 10
ER -