TY - JOUR
T1 - Sibling History of Myocardial Infarction or Stroke and Risk of Cardiovascular Disease in the Elderly
T2 - The Cardiovascular Health Study
AU - Yanez, N. David
AU - Burke, Gregory L.
AU - Manolio, Teri
AU - Gardin, Julius M.
AU - Polak, Joseph
N1 - Funding Information:
The research reported in this article was supported by contract numbers N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, grant number U01 HL080295 from the National Heart, Lung, and Blood Institute, with additional contribution from the National Institute of Neurological Disorders and Stroke . Additional support was provided through R01 AG-15928, R01 AG-20098, and AG-027058 from the National Institute on Aging; R01 HL-075366 from the National Heart, Lung and Blood Institute; and the University of Pittsburgh Claude. D. Pepper Older Americans Independence Center P30-AG-024827.
PY - 2009/12
Y1 - 2009/12
N2 - Purpose: To assess the relationship between sibling history of myocardial infarction (MI) or stroke with cardiovascular disease (CVD) and risk factors in older adults. Methods: Prospective cohort study of 5,888 older adults participating in the Cardiovascular Health Study (CHS). History of MI and stroke in siblings was obtained by self-report. Participants with positive sibling histories were compared to those with negative histories to determine if prevalent or incident disease (coronary heart disease [CHD], MI, stroke, angina), subclinical CVD (carotid wall thickness, left ventricular mass, hypertension, diabetes, ankle-brachial index), CVD risk factors differed between groups. Results: More than 91% (n=5,383) of CHS participants reported at least one sibling. Sibling history of MI was associated with increased disease prevalence (CHD, MI, angina) and incidence (CHD, angina). Sibling history of stroke was associated with increased disease prevalence (CHD, angina). Sibling history of either MI or stroke was associated with increased disease prevalence and incidence for CHD, MI and angina, more subclinical disease, and a higher CVD risk profile. Conclusions: Sibling history of MI and stroke were markers of higher CVD risk status even in older adults. Of clinical importance, participants with positive sibling history have numerous risk factors amenable to intervention.
AB - Purpose: To assess the relationship between sibling history of myocardial infarction (MI) or stroke with cardiovascular disease (CVD) and risk factors in older adults. Methods: Prospective cohort study of 5,888 older adults participating in the Cardiovascular Health Study (CHS). History of MI and stroke in siblings was obtained by self-report. Participants with positive sibling histories were compared to those with negative histories to determine if prevalent or incident disease (coronary heart disease [CHD], MI, stroke, angina), subclinical CVD (carotid wall thickness, left ventricular mass, hypertension, diabetes, ankle-brachial index), CVD risk factors differed between groups. Results: More than 91% (n=5,383) of CHS participants reported at least one sibling. Sibling history of MI was associated with increased disease prevalence (CHD, MI, angina) and incidence (CHD, angina). Sibling history of stroke was associated with increased disease prevalence (CHD, angina). Sibling history of either MI or stroke was associated with increased disease prevalence and incidence for CHD, MI and angina, more subclinical disease, and a higher CVD risk profile. Conclusions: Sibling history of MI and stroke were markers of higher CVD risk status even in older adults. Of clinical importance, participants with positive sibling history have numerous risk factors amenable to intervention.
KW - Atherosclerosis
KW - Cardiovascular Diseases
KW - Epidemiology
KW - Lifestyle
KW - Risk Factors
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U2 - 10.1016/j.annepidem.2009.07.095
DO - 10.1016/j.annepidem.2009.07.095
M3 - Article
C2 - 19944349
AN - SCOPUS:70449955000
SN - 1047-2797
VL - 19
SP - 858
EP - 866
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 12
ER -