Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone. A preliminary report

F. Comite, G. B. Cutler, J. Rivier, W. W. Vale, Donald (Lynn) Loriaux, W. F. Crowley

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Abstract

The uncoupling of pituitary stimulation and response observed in adults during administration of the luteinizing hormone-releasing hormone analogue, D-Trp6-Pro9-NEt-LHLRH (LHRH(a)) suggested that this drug might be useful in treating precocious puberty. We treated five girls with idiopathic precocious puberty (ages two to eight) for eight weeks with daily subcutaneous injections of LHRH(a). The patients had Tanner II to IV pubertal development, advanced bone age, and estrogen effect on vaginal smear, measurable basal gonadotropin levels with pulsed nocturnal secretion, and a pubertal gonadotropin response to LHRH. Irregular vaginal bleeding was present in three patients. LHRH(a) significantly decreased basal (P <0.025) and LHRH-stimulated (P <0.01) gonadotropin levels as well as serum estradiol (P

Original languageEnglish (US)
Pages (from-to)1546-1550
Number of pages5
JournalNew England Journal of Medicine
Volume305
Issue number26
StatePublished - 1981
Externally publishedYes

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Precocious Puberty
Gonadotropin-Releasing Hormone
Gonadotropins
Therapeutics
Vaginal Smears
Uterine Hemorrhage
Bone Development
Subcutaneous Injections
Estradiol
Estrogens
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

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Short-term treatment of idiopathic precocious puberty with a long-acting analogue of luteinizing hormone-releasing hormone. A preliminary report. / Comite, F.; Cutler, G. B.; Rivier, J.; Vale, W. W.; Loriaux, Donald (Lynn); Crowley, W. F.

In: New England Journal of Medicine, Vol. 305, No. 26, 1981, p. 1546-1550.

Research output: Contribution to journalArticle

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AU - Vale, W. W.

AU - Loriaux, Donald (Lynn)

AU - Crowley, W. F.

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