Short message service (SMS) reminders and real-time adherence monitoring improve antiretroviral therapy adherence in rural Uganda

Jessica E. Haberer, Angella Musiimenta, Esther C. Atukunda, Nicholas Musinguzi, Monique A. Wyatt, Norma C. Ware, David R. Bangsberg

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Objective: To explore the effects of four types of short message service (SMS) plus real-time adherence monitoring on antiretroviral therapy (ART) adherence: daily reminders, weekly reminders, reminders triggered after a late or missed dose (delivered to patients), and notifications triggered by sustained adherence lapses (delivered to patient-nominated social supporters). Design: Pilot randomized controlled trial. Methods: Sixty-three individuals initiating ART received a real-time adherence monitor and were randomized (1:1:1):(1) Scheduled SMS reminders (daily for 1 month, weekly for 2 months), then SMS reminders triggered by a late or missed dose (no monitoring signal within 2h of expected dosing); SMS notifications to social supporters for sustained adherence lapses (no monitoring signal for >48h) added after 3 months. (2) Triggered SMS reminders starting at enrolment; SMS notifications to social supporters added after 3 months. (3) Control: No SMS. HIV RNA was determined at 9 months. Percentage adherence and adherence lapses were compared by linear generalized estimating equations and Poisson regression, respectively. Results: Median age was 31 years, 65% were women, and median enrolment CD4+ cell count was 322cells/μl 97% took once daily tenofovir/emtricitabine/efavirenz. Compared to control, adherence was 11.1% higher (P=0.04) and more than 48-h lapses were less frequent (IRR 0.6, P=0.02) in the scheduled SMS arm. Adherence and more than 48-h lapses were similar in the triggered SMS arm and control. No differences in HIV RNA were seen. Conclusion: Scheduled SMS reminders improved ART in the context of real-time monitoring. Larger studies are needed to determine the impact of triggered reminders and role of social supporters in improving adherence.

Original languageEnglish (US)
Pages (from-to)1295-1299
Number of pages5
JournalAIDS
Volume30
Issue number8
DOIs
StatePublished - May 15 2016

Keywords

  • antiretroviral therapy
  • real-time adherence monitoring
  • short message service (SMS)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Short message service (SMS) reminders and real-time adherence monitoring improve antiretroviral therapy adherence in rural Uganda'. Together they form a unique fingerprint.

  • Cite this