Shoe allergens

Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2004

Erin M. Warshaw, Sarah E. Schram, Donald V. Belsito, Vincent A. DeLeo, Joseph F. Fowler, Howard I. Maibach, James G. Marks, C. G Toby Mathias, Melanie D. Pratt, Robert L. Rietschel, Denis Sasseville, Frances Storrs, James S. Taylor, Kathryn A. Zug

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: Chemicals used in leather tanning, rubber processing, and/or adhesives are the most often-cited culprits in footwear dermatitis. Patch testing patients with suspected shoe dermatitis is essential for diagnosis and management. Objectives: The four goals for this study were to (1) determine the frequency of allergens associated with a shoe source in North American Contact Dermatitis Group (NACDG) patients with footwear allergic contact dermatitis; (2) compare these results to allergen frequencies from other published studies; (3) quantify the number of shoe-related reactions that were not identified with the NACDG standard series; and (4) identify relevant allergens not included on the NACDG standard series, based on data from other published studies. Methods: The NACDG patch-tested 10,061 patients between 2001 and 2004. Data were retrospectively analyzed by (1) allergen source coded as "shoe," (2) site of dermatitis as "feet," and (3) diagnosis of "allergic contact dermatitis." Results: Among the 109 NACDG patients with allergic contact dermatitis (ACD) of the foot and a shoe source of allergens, p-tertiary butylphenol formaldehyde resin, an adhesive, was the most common allergen, accounting for 24.7% of positive patch-test results, followed by potassium dichromate (17.5%) and carba mix (11.7%). When the data were examined according to groups of allergens, rubber chemicals (40.4%) were the most frequent allergens, followed by adhesives (32.5%), and leather components (20.1%). When data from published studies were pooled, potassium dichromate (31.5%) was the most frequent allergen, followed by p-tertiary butylphenol formaldehyde resin (17.1%) and cobalt chloride (12.9%). NACDG patients were statistically more likely to have positive patch-test reactions to p-tertiary butylphenol formaldehyde resin and statistically less likely to have a positive patch-test reaction to potassium dichromate than patients represented in pooled data from past studies. Nineteen (17.4%) of the 109 NACDG patients with ACD of the foot and a shoe source of allergens were identified as having a shoe source of a relevant allergen not included in the NACDG standard series. Conclusions: In NACDG patients, the most common individual shoe allergen was p-tertiary butylphenol formaldehyde resin. As a group, rubber chemicals were most common, a finding consistent with those of other studies.

Original languageEnglish (US)
Pages (from-to)191-202
Number of pages12
JournalDermatitis
Volume18
Issue number4
DOIs
StatePublished - Dec 2007
Externally publishedYes

Fingerprint

Shoes
Contact Dermatitis
Allergens
Cross-Sectional Studies
Allergic Contact Dermatitis
Potassium Dichromate
Formaldehyde
Patch Tests
Rubber
Dermatitis
Adhesives
Foot
Tanning

ASJC Scopus subject areas

  • Dermatology

Cite this

Warshaw, E. M., Schram, S. E., Belsito, D. V., DeLeo, V. A., Fowler, J. F., Maibach, H. I., ... Zug, K. A. (2007). Shoe allergens: Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2004. Dermatitis, 18(4), 191-202. https://doi.org/10.2310/6620.2007.06047

Shoe allergens : Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2004. / Warshaw, Erin M.; Schram, Sarah E.; Belsito, Donald V.; DeLeo, Vincent A.; Fowler, Joseph F.; Maibach, Howard I.; Marks, James G.; Mathias, C. G Toby; Pratt, Melanie D.; Rietschel, Robert L.; Sasseville, Denis; Storrs, Frances; Taylor, James S.; Zug, Kathryn A.

In: Dermatitis, Vol. 18, No. 4, 12.2007, p. 191-202.

Research output: Contribution to journalArticle

Warshaw, EM, Schram, SE, Belsito, DV, DeLeo, VA, Fowler, JF, Maibach, HI, Marks, JG, Mathias, CGT, Pratt, MD, Rietschel, RL, Sasseville, D, Storrs, F, Taylor, JS & Zug, KA 2007, 'Shoe allergens: Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2004', Dermatitis, vol. 18, no. 4, pp. 191-202. https://doi.org/10.2310/6620.2007.06047
Warshaw, Erin M. ; Schram, Sarah E. ; Belsito, Donald V. ; DeLeo, Vincent A. ; Fowler, Joseph F. ; Maibach, Howard I. ; Marks, James G. ; Mathias, C. G Toby ; Pratt, Melanie D. ; Rietschel, Robert L. ; Sasseville, Denis ; Storrs, Frances ; Taylor, James S. ; Zug, Kathryn A. / Shoe allergens : Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2004. In: Dermatitis. 2007 ; Vol. 18, No. 4. pp. 191-202.
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abstract = "Background: Chemicals used in leather tanning, rubber processing, and/or adhesives are the most often-cited culprits in footwear dermatitis. Patch testing patients with suspected shoe dermatitis is essential for diagnosis and management. Objectives: The four goals for this study were to (1) determine the frequency of allergens associated with a shoe source in North American Contact Dermatitis Group (NACDG) patients with footwear allergic contact dermatitis; (2) compare these results to allergen frequencies from other published studies; (3) quantify the number of shoe-related reactions that were not identified with the NACDG standard series; and (4) identify relevant allergens not included on the NACDG standard series, based on data from other published studies. Methods: The NACDG patch-tested 10,061 patients between 2001 and 2004. Data were retrospectively analyzed by (1) allergen source coded as {"}shoe,{"} (2) site of dermatitis as {"}feet,{"} and (3) diagnosis of {"}allergic contact dermatitis.{"} Results: Among the 109 NACDG patients with allergic contact dermatitis (ACD) of the foot and a shoe source of allergens, p-tertiary butylphenol formaldehyde resin, an adhesive, was the most common allergen, accounting for 24.7{\%} of positive patch-test results, followed by potassium dichromate (17.5{\%}) and carba mix (11.7{\%}). When the data were examined according to groups of allergens, rubber chemicals (40.4{\%}) were the most frequent allergens, followed by adhesives (32.5{\%}), and leather components (20.1{\%}). When data from published studies were pooled, potassium dichromate (31.5{\%}) was the most frequent allergen, followed by p-tertiary butylphenol formaldehyde resin (17.1{\%}) and cobalt chloride (12.9{\%}). NACDG patients were statistically more likely to have positive patch-test reactions to p-tertiary butylphenol formaldehyde resin and statistically less likely to have a positive patch-test reaction to potassium dichromate than patients represented in pooled data from past studies. Nineteen (17.4{\%}) of the 109 NACDG patients with ACD of the foot and a shoe source of allergens were identified as having a shoe source of a relevant allergen not included in the NACDG standard series. Conclusions: In NACDG patients, the most common individual shoe allergen was p-tertiary butylphenol formaldehyde resin. As a group, rubber chemicals were most common, a finding consistent with those of other studies.",
author = "Warshaw, {Erin M.} and Schram, {Sarah E.} and Belsito, {Donald V.} and DeLeo, {Vincent A.} and Fowler, {Joseph F.} and Maibach, {Howard I.} and Marks, {James G.} and Mathias, {C. G Toby} and Pratt, {Melanie D.} and Rietschel, {Robert L.} and Denis Sasseville and Frances Storrs and Taylor, {James S.} and Zug, {Kathryn A.}",
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T1 - Shoe allergens

T2 - Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2004

AU - Warshaw, Erin M.

AU - Schram, Sarah E.

AU - Belsito, Donald V.

AU - DeLeo, Vincent A.

AU - Fowler, Joseph F.

AU - Maibach, Howard I.

AU - Marks, James G.

AU - Mathias, C. G Toby

AU - Pratt, Melanie D.

AU - Rietschel, Robert L.

AU - Sasseville, Denis

AU - Storrs, Frances

AU - Taylor, James S.

AU - Zug, Kathryn A.

PY - 2007/12

Y1 - 2007/12

N2 - Background: Chemicals used in leather tanning, rubber processing, and/or adhesives are the most often-cited culprits in footwear dermatitis. Patch testing patients with suspected shoe dermatitis is essential for diagnosis and management. Objectives: The four goals for this study were to (1) determine the frequency of allergens associated with a shoe source in North American Contact Dermatitis Group (NACDG) patients with footwear allergic contact dermatitis; (2) compare these results to allergen frequencies from other published studies; (3) quantify the number of shoe-related reactions that were not identified with the NACDG standard series; and (4) identify relevant allergens not included on the NACDG standard series, based on data from other published studies. Methods: The NACDG patch-tested 10,061 patients between 2001 and 2004. Data were retrospectively analyzed by (1) allergen source coded as "shoe," (2) site of dermatitis as "feet," and (3) diagnosis of "allergic contact dermatitis." Results: Among the 109 NACDG patients with allergic contact dermatitis (ACD) of the foot and a shoe source of allergens, p-tertiary butylphenol formaldehyde resin, an adhesive, was the most common allergen, accounting for 24.7% of positive patch-test results, followed by potassium dichromate (17.5%) and carba mix (11.7%). When the data were examined according to groups of allergens, rubber chemicals (40.4%) were the most frequent allergens, followed by adhesives (32.5%), and leather components (20.1%). When data from published studies were pooled, potassium dichromate (31.5%) was the most frequent allergen, followed by p-tertiary butylphenol formaldehyde resin (17.1%) and cobalt chloride (12.9%). NACDG patients were statistically more likely to have positive patch-test reactions to p-tertiary butylphenol formaldehyde resin and statistically less likely to have a positive patch-test reaction to potassium dichromate than patients represented in pooled data from past studies. Nineteen (17.4%) of the 109 NACDG patients with ACD of the foot and a shoe source of allergens were identified as having a shoe source of a relevant allergen not included in the NACDG standard series. Conclusions: In NACDG patients, the most common individual shoe allergen was p-tertiary butylphenol formaldehyde resin. As a group, rubber chemicals were most common, a finding consistent with those of other studies.

AB - Background: Chemicals used in leather tanning, rubber processing, and/or adhesives are the most often-cited culprits in footwear dermatitis. Patch testing patients with suspected shoe dermatitis is essential for diagnosis and management. Objectives: The four goals for this study were to (1) determine the frequency of allergens associated with a shoe source in North American Contact Dermatitis Group (NACDG) patients with footwear allergic contact dermatitis; (2) compare these results to allergen frequencies from other published studies; (3) quantify the number of shoe-related reactions that were not identified with the NACDG standard series; and (4) identify relevant allergens not included on the NACDG standard series, based on data from other published studies. Methods: The NACDG patch-tested 10,061 patients between 2001 and 2004. Data were retrospectively analyzed by (1) allergen source coded as "shoe," (2) site of dermatitis as "feet," and (3) diagnosis of "allergic contact dermatitis." Results: Among the 109 NACDG patients with allergic contact dermatitis (ACD) of the foot and a shoe source of allergens, p-tertiary butylphenol formaldehyde resin, an adhesive, was the most common allergen, accounting for 24.7% of positive patch-test results, followed by potassium dichromate (17.5%) and carba mix (11.7%). When the data were examined according to groups of allergens, rubber chemicals (40.4%) were the most frequent allergens, followed by adhesives (32.5%), and leather components (20.1%). When data from published studies were pooled, potassium dichromate (31.5%) was the most frequent allergen, followed by p-tertiary butylphenol formaldehyde resin (17.1%) and cobalt chloride (12.9%). NACDG patients were statistically more likely to have positive patch-test reactions to p-tertiary butylphenol formaldehyde resin and statistically less likely to have a positive patch-test reaction to potassium dichromate than patients represented in pooled data from past studies. Nineteen (17.4%) of the 109 NACDG patients with ACD of the foot and a shoe source of allergens were identified as having a shoe source of a relevant allergen not included in the NACDG standard series. Conclusions: In NACDG patients, the most common individual shoe allergen was p-tertiary butylphenol formaldehyde resin. As a group, rubber chemicals were most common, a finding consistent with those of other studies.

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