Sex differences in vasopressin neurons in the bed nucleus of the stria terminalis by in situ hybridization

Margaret A. Miller, Linda Vician, Donald K. Clifton, Daniel M. Dorsa

Research output: Contribution to journalArticle

108 Scopus citations

Abstract

To determine whether a sex difference exists in the biosynthetic capacity of vasopressinergic (AVP) neurons in the bed nucleus of the stria terminalis (BNST), we have used in situ hybridization and quantitative autoradiography to measure propressophysin messenger RNA levels in these cells from adult male and female rats. We have found that significantly more (p<0.01) neurons are labeled in male rats than in female rats and that these labeled cells averaged more grains/cell (p<0.05) in males than in females. Therefore, the sexual dimorphism of AVP pathways in the BNST and lateral septum recently shown by immunohistochemistry results from a sex difference in the biosynthetic capacity of these AVP neurons.

Original languageEnglish (US)
Pages (from-to)615-619
Number of pages5
JournalPeptides
Volume10
Issue number3
DOIs
StatePublished - Jan 1 1989

Keywords

  • BNST
  • In situ hybridization
  • Sex differences
  • Vasopressin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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