Severe ocular and orbital toxicity after intracarotid etoposide phosphate and carboplatin therapy

Andreas Katsuya Lauer, John L. Wobig, William T. Shults, Edward A. Neuwelt, Matthew W. Wilson

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

PURPOSE: To report severe ocular and orbital toxicity after administration of intracarotid etoposide phosphate and carboplatin. METHOD: Case report. RESULTS: A 52-year-old man with glioblastoma multi- forme underwent left intracarotid administration of etoposide phosphate and carboplastin inferior to the ophthalmic artery. Within 7 hours, a nonpupillary block angle-closure glaucoma developed secondary to uveal effusion in the ipsilateral eye, which was relieved by cycloplegia. Four days later, severe orbital inflammation resulted in a visual acuity of counting fingers, proptosis, optic neuropathy, and total external ophthalmoplegia in the eye. The patient's condition improved after a lateral cantholysis and administration of high-dose intravenous corticosteroids. Two weeks later, an anterior uveitis occurred in the left eye, which responded to topical corticosteroids. During a 2-month period, the patient recovered to a visual acuity of 20/70, near normal motility, and normal intraocular pressure, and the ocular and orbital inflammation resolved. Preexisting ipsilateral chemotherapy-induced maculopathy became more pronounced. CONCLUSION: Ocular and orbital toxicity after intracarotid etoposide phosphate and carboplatin therapy is infrequently reported.

Original languageEnglish (US)
Pages (from-to)230-233
Number of pages4
JournalAmerican journal of ophthalmology
Volume127
Issue number2
DOIs
StatePublished - Feb 1999

ASJC Scopus subject areas

  • Ophthalmology

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