Serum arabinitol concentrations and arabinitol/creatinine ratios in invasive candidiasis

Jonathan W.M. Gold, Brian Wong, Edward M. Bernard, Timothy E. Kiehn, Donald Armstrong

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Serum arabinitol concentrations and arabinitol/creatinine ratios were determined in 25 cancer patients with invasive candidiasis, 73 severely ill cancer patients who did not have invasive candidiasis, and 125 uninfected patients with chronic renal failure. Elevated arabinitol concentrations were found in patients with renal failure and invasive candidiasis. Serum arabinitol concentrations exceeded 1.19 μg/ml in 13 of 18 patients with invasive candidiasis who were studied when renal function was normal and in three of 52 control patients. Among patients with renal failure, 10 of 14 with invasive candidiasis but only four of 36 control patients had serum arabinitol concentrations of >5.85 μg/ml. Serum arabinitol and creatinine concentrations were strongly correlated. The arabinitol/creatinine ratio exceeded 1.5 in 16 of 25 patients with invasive candidiasis but in only three of 88 control patients. Increased serum arabinitol concentrations appear to reflect increased production of arabinitol by yeast in individuals with invasive candidiasis.

Original languageEnglish (US)
Pages (from-to)504-513
Number of pages10
JournalUnknown Journal
Volume147
Issue number3
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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