Serum antibodies against feline oncornavirus-associated cell membrane antigen in cats bearing virally induced uveal melanomas

J. Y. Niederkorn, J. A. Shadduck, D. Albert, M. Essex

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The humoral immune response to a virally induced feline model of human uveal melanoma was studied by examining sera from cats bearing iridal and choroidal melanomas for antibody to the feline oncornavirus-associated cell membrane antigen (FOCMA). Anti-FOCMA antibodies appeared earlier and in higher titers in cats that ultimately expressed nonprogressing uveal melanomas. By 8 weeks after virus inoculation 56% of the cats with nonprogressing lesions had anti-FOCMA antibodies, whereas only 7% of the cats with progressive tumors produced demonstrable antibodies against FOCMA. Mean serum antibody titers were approximately 10 times higher in cats with nonprogressive lesions than in cats with progressive tumors. Similar trends were observed throughout the 28-week study period. Early appearance and a high titer of serum antibody against FOCMA correlated with nonprogressing uveal melanoma. The results indicated that uveal melanomas could be immunogeneic and successfully managed by the host's immune system.

Original languageEnglish (US)
Pages (from-to)598-605
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume20
Issue number5
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Serum antibodies against feline oncornavirus-associated cell membrane antigen in cats bearing virally induced uveal melanomas'. Together they form a unique fingerprint.

  • Cite this