Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men

Jane A. Cauley, Neeta Parimi, Kristine E. Ensrud, Douglas C. Bauer, Peggy M. Cawthon, Steven R. Cummings, Andrew R. Hoffman, James M. Shikany, Elizabeth Barrett-Connor, Eric Orwoll

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

The association between vitamin D levels and incident fractures in older men is uncertain. To test the hypothesis that low serum 25-hydroxyvitamin D [(25(OH)D] levels are associated with an increased risk of fracture, we performed a case-cohort study of 436 men with incident nonspine fractures, including 81 hip fractures, and a random subcohort of 1608 men; average follow-up time 5.3 years. Serum vitamin D2 and vitamin D3 were measured on baseline sera using mass spectrometry and summed for total vitamin D. Modified Cox proportional hazards models were used to estimate the hazard ratio (HR) of fracture with 95% confidence intervals (CIs). Multivariable models included age, clinic, season, race, height, weight, and physical activity. The mean (SD) total 25(OH)D was 24.6 (7.8) ng/mL in nonspine fracture subjects, 21.5 (7.9) ng/mL in hip fracture subjects, and 25.2 (7.8) ng/mL in controls (nonspine fracture subjects versus nonpatients, p = .14; hip fracture subjects versus controls, p <.0001). 25(OH)D levels were unrelated to nonspine fractures. One SD decrease in total 25(OH)D was associated with an increased risk of hip fracture (multivariate HR = 1.60; 95% CI 1.18-2.17). Compared with men in the top quartile of total 25(OH)D (≥28), the HR of hip fracture was 2.36 (95% CI 1.08-5.15) for men in the lowest quartile (

Original languageEnglish (US)
Pages (from-to)545-553
Number of pages9
JournalJournal of Bone and Mineral Research
Volume25
Issue number3
DOIs
StatePublished - 2010

Fingerprint

Hip Fractures
Serum
Confidence Intervals
Vitamin D
Ergocalciferols
Cholecalciferol
Proportional Hazards Models
Mass Spectrometry
Cohort Studies
25-hydroxyvitamin D
Exercise
Weights and Measures

Keywords

  • Hip fracture
  • MrOS
  • Nonspine fracture
  • Older men
  • Vitamin D

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Cauley, J. A., Parimi, N., Ensrud, K. E., Bauer, D. C., Cawthon, P. M., Cummings, S. R., ... Orwoll, E. (2010). Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. Journal of Bone and Mineral Research, 25(3), 545-553. https://doi.org/10.1359/jbmr.090826

Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. / Cauley, Jane A.; Parimi, Neeta; Ensrud, Kristine E.; Bauer, Douglas C.; Cawthon, Peggy M.; Cummings, Steven R.; Hoffman, Andrew R.; Shikany, James M.; Barrett-Connor, Elizabeth; Orwoll, Eric.

In: Journal of Bone and Mineral Research, Vol. 25, No. 3, 2010, p. 545-553.

Research output: Contribution to journalArticle

Cauley, JA, Parimi, N, Ensrud, KE, Bauer, DC, Cawthon, PM, Cummings, SR, Hoffman, AR, Shikany, JM, Barrett-Connor, E & Orwoll, E 2010, 'Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men', Journal of Bone and Mineral Research, vol. 25, no. 3, pp. 545-553. https://doi.org/10.1359/jbmr.090826
Cauley, Jane A. ; Parimi, Neeta ; Ensrud, Kristine E. ; Bauer, Douglas C. ; Cawthon, Peggy M. ; Cummings, Steven R. ; Hoffman, Andrew R. ; Shikany, James M. ; Barrett-Connor, Elizabeth ; Orwoll, Eric. / Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. In: Journal of Bone and Mineral Research. 2010 ; Vol. 25, No. 3. pp. 545-553.
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