Serous Retinopathy Associated with Mitogen-Activated Protein Kinase Kinase Inhibition (Binimetinib) for Metastatic Cutaneous and Uveal Melanoma

Elon H C Van Dijk, Carla M L Van Herpen, Marina Marinkovic, John B A G Haanen, Drake Amundson, Gré P M Luyten, Martine J. Jager, Ellen H W Kapiteijn, Jan E E Keunen, Grazyna Adamus, Camiel J F Boon

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27 Scopus citations

Abstract

Purpose To analyze the clinical characteristics of a serous retinopathy associated with mitogen-activated protein kinase kinase (MEK) inhibition with binimetinib treatment for metastatic cutaneous melanoma (CM) and uveal melanoma (UM), and to determine possible pathogenetic mechanisms that may lead to this retinopathy. Design Prospective observational, cohort-based, cross-sectional study. Participants Thirty CM patients and 5 UM patients treated with the MEK inhibitor binimetinib (CM) or a combination of binimetinib and the protein kinase C inhibitor sotrastaurin (UM). Methods Extensive ophthalmic examination was performed, including Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, applanation tonometry, slit-lamp examination, indirect ophthalmoscopy, digital color fundus photography, and optical coherence tomography (OCT). In selected cases, additional examinations were performed, including visual field testing and electro-oculography (EOG). Blood samples were obtained from 3 CM patients and 3 UM patients to analyze the presence of autoantibodies against retinal and retinal pigment epithelium (RPE) proteins. Main Outcome Measures Visual symptoms, visual acuity, fundus appearance, characteristics on OCT, fundus autofluorescence (FAF), and EOG. Results Six CM patients (20%) and 2 UM patients (40%) reported visual symptoms during the study. The median time to the onset of symptoms, which were all mild and transient, was 3.5 days (range,

Original languageEnglish (US)
Pages (from-to)1907-1916
Number of pages10
JournalOphthalmology
Volume122
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

Van Dijk, E. H. C., Van Herpen, C. M. L., Marinkovic, M., Haanen, J. B. A. G., Amundson, D., Luyten, G. P. M., ... Boon, C. J. F. (2015). Serous Retinopathy Associated with Mitogen-Activated Protein Kinase Kinase Inhibition (Binimetinib) for Metastatic Cutaneous and Uveal Melanoma. Ophthalmology, 122(9), 1907-1916. https://doi.org/10.1016/j.ophtha.2015.05.027