Serotonin 5-HT2 receptor availability in chronic cocaine abusers

Gene Jack Wang, Nora D. Volkow, Jean Logon, Joanna S. Fowler, David Schlyer, Robert R. MacGregor, Robert J. Hitzemann, Albert Gjedde, Alfred P. Wolf

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Serotonin 5-HT2 receptor availability was evaluated in chronic cocaine abusers (n = 19) using positron emission tomography and F-18 N-methylspiperone and was compared to control subjects (n = 19). 5-HT2 Receptor availability was measured in frontal, occipital, cingulate and orbitofrontal cortices using the ratio of the distribution volume in the region of interest to that in the cerebellum which is a function of Bmax/Kd- 5-HT2 Receptor availability was significantly higer in cingulate and orbitofrontal cortices than in other frontal regions or occipital cortex. The values were not different in normal subjects and cocaine abusers. These results did not show any changes in 5-HT2 receptor availability in cocaine abusers as compared to the control subjects.

Original languageEnglish (US)
Pages (from-to)PL299-PL303
JournalLife Sciences
Volume56
Issue number16
DOIs
StatePublished - Mar 10 1995

Keywords

  • chronic cocaine abuse
  • receptor availability
  • serotonin 5-HT

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Wang, G. J., Volkow, N. D., Logon, J., Fowler, J. S., Schlyer, D., MacGregor, R. R., Hitzemann, R. J., Gjedde, A., & Wolf, A. P. (1995). Serotonin 5-HT2 receptor availability in chronic cocaine abusers. Life Sciences, 56(16), PL299-PL303. https://doi.org/10.1016/0024-3205(95)00090-9