Serial two-dimensional echocardiography in duchenne muscular dystrophy

Stanley J. Goldberg, Lawrence Z. Stern, Linda Feldman, Hugh D. Allen, David J. Sahn, Lilliam M. Valdes-Cruz

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Patients with Duchenne muscular dystrophy (DMD) are known to have progressive epicardial fibrosis of the free wall of the left ventricle, but standard noninvasive M-mode echocardiographic tests of left ventricular function are relatively insensitive detectors of this cardiomyopathy. We therefore used two-dimensional echocardiography to record three short axis levels of the left ventricle in 13 Duchenne patients. Serial studies were separated by 2 years for most patients. The two-dimensional echocardiographic technique allows qualitative evaluation of segmental contraction of the left ventricle. Four general principles were found during this study: (1) Obvious contraction abnormalities of the left ventricle were present in most patients with DMD. (2) In most patients, the contraction deficit was first noted in the left ventricular posterior free wall behind the mitral valve. (3) Once a contraction deficit was observed, the area of abnormal contraction progressed inferiorly to include additional areas of the left ventricular posterior free wall. (4) Standard M-mode left ventricular function techniques were unreliable for detecting individuals with segmental contraction abnormalities.

Original languageEnglish (US)
Pages (from-to)1101-1105
Number of pages5
JournalNeurology
Volume32
Issue number10
DOIs
StatePublished - Oct 1982

ASJC Scopus subject areas

  • Clinical Neurology

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    Goldberg, S. J., Stern, L. Z., Feldman, L., Allen, H. D., Sahn, D. J., & Valdes-Cruz, L. M. (1982). Serial two-dimensional echocardiography in duchenne muscular dystrophy. Neurology, 32(10), 1101-1105. https://doi.org/10.1212/wnl.32.10.1101