Sensitivity to reinforcer delay predicts ethanol's suppressant effects, but itself is unaffected by ethanol

Travis M. Moschak, Suzanne Mitchell

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Relative preference for smaller, sooner rewards over larger, later rewards ("delay discounting") is increased by acute ethanol. Additionally, drug-naïve levels of delay discounting can predict subsequent ethanol consumption. However, it is unknown whether these phenomena are driven by a difference in sensitivity to the reinforcer delay or a difference in sensitivity to the reinforcer magnitude, because typical delay discounting tasks manipulate both parameters simultaneously. Methods: To disambiguate these factors, two tasks were developed in which animals chose between levers with either different delay contingencies (adjusting delay task) or different magnitude contingencies (adjusting magnitude task). When task performance was stable, rats received ethanol (0, 0.6, and 0.9. g/kg, i.p.). Results: Ethanol did not affect sensitivity to delay or sensitivity to magnitude. However, responding was suppressed at the highest dose of ethanol (0.9. g/kg). Less suppression was found in animals exhibiting high levels of drug-naïve sensitivity to delay. Conclusion: Thus, this study suggests that ethanol's effect on standard delay discounting tasks is not due to an alteration in sensitivity to delay or magnitude. Additionally, these data show that animals with high sensitivity to delay are resistant to the behaviorally suppressant effects of ethanol, which suggests that low tolerance for delayed rewards and low sensitivity to the behaviorally suppressant effects of ethanol may partly be driven by the same underlying mechanism.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
JournalDrug and Alcohol Dependence
Volume132
Issue number1-2
DOIs
StatePublished - Sep 1 2013

Fingerprint

Ethanol
Reward
Animals
Task Performance and Analysis
Pharmaceutical Preparations
Rats
Delay Discounting

Keywords

  • Delay discounting
  • Ethanol
  • Impulsivity
  • Intertemporal choice
  • Low level of response to alcohol

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Toxicology
  • Pharmacology
  • Pharmacology (medical)

Cite this

Sensitivity to reinforcer delay predicts ethanol's suppressant effects, but itself is unaffected by ethanol. / Moschak, Travis M.; Mitchell, Suzanne.

In: Drug and Alcohol Dependence, Vol. 132, No. 1-2, 01.09.2013, p. 22-28.

Research output: Contribution to journalArticle

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