Sensitivity to ethanol-induced motor incoordination in 5-HT(1B) receptor null mutant mice is task-dependent: Implications for behavioral assessment of genetically altered mice

Stephen L. Boehm, Gwen L. Schafer, Tamara J. Phillips, Kaitlin E. Browman, John C. Crabbe

Research output: Contribution to journalArticle

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Neuromuscular impairment by ethanol likely involves complex effects on balance, gait, muscle strength, and other features of motor coordination. The present experiments showed that relative sensitivity to ethanol-induced motor impairment in serotonin 1B (5-HT(1B)) null mutant and control mice was task dependent. We found that ethanol-treated null mutant mice made fewer missteps on a balance beam than did ethanol-treated wild-type mice, and confirmed a previous finding of their lesser ethanol sensitivity in the grid test. The genotypes did not differ in ethanol sensitivity as measured by the screen test, static dowel, fixed-speed rotarod, accelerating rotarod, grip strength, or loss of righting reflex tests. These experiments suggest that within a behavioral domain, alternative tests of function are not equivalent, so multiple assessment tools should be used to avoid misinterpretation of gene function.

Original languageEnglish (US)
Pages (from-to)401-409
Number of pages9
JournalBehavioral Neuroscience
Issue number2
StatePublished - Jan 1 2000


ASJC Scopus subject areas

  • Behavioral Neuroscience

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