Selenium for the prevention of cutaneous melanoma

Pamela Cassidy, Heidi D. Fain, James P. Cassidy, Sally M. Tran, Philip J. Moos, Kenneth M. Boucher, Russell Gerads, Scott R. Florell, Douglas Grossman, Sancy Leachman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process of cutaneous melanomagenisis, and to examine the utility of two different chemical forms of Se for prevention and treatment of melanoma. We studied the effects of Se in vitro on UV-induced oxidative stress in melanocytes, and on apoptosis and cell cycle progression in melanoma cells. In vivo, we used the HGF transgenic mouse model of UV-induced melanoma to demonstrate that topical treatment with L-selenomethionine results in a significant delay in the time required for UV-induced melanoma development, but also increases the rate of growth of those tumors once they appear. In a second mouse model, we found that oral administration of high dose methylseleninic acid significantly decreases the size of human melanoma xenografts. Our findings suggest that modestly elevation of selenium levels in the skin might risk acceleration of growth of incipient tumors. Additionally, certain Se compounds administered at very high doses could have utility for the treatment of fully-malignant tumors or prevention of recurrence.

Original languageEnglish (US)
Pages (from-to)725-749
Number of pages25
JournalNutrients
Volume5
Issue number3
DOIs
StatePublished - Mar 7 2013
Externally publishedYes

Fingerprint

melanoma
Selenium
selenium
Melanoma
Skin
neoplasms
Neoplasms
Selenium Compounds
Selenomethionine
animal models
Melanocytes
selenomethionine
Therapeutics
Growth
Nutritional Status
melanocytes
Heterografts
Transgenic Mice
Oral Administration
dosage

Keywords

  • HGF mouse
  • Melanoma
  • Methylseleninic acid
  • Selenium
  • Selenomethionine

ASJC Scopus subject areas

  • Food Science

Cite this

Cassidy, P., Fain, H. D., Cassidy, J. P., Tran, S. M., Moos, P. J., Boucher, K. M., ... Leachman, S. (2013). Selenium for the prevention of cutaneous melanoma. Nutrients, 5(3), 725-749. https://doi.org/10.3390/nu5030725

Selenium for the prevention of cutaneous melanoma. / Cassidy, Pamela; Fain, Heidi D.; Cassidy, James P.; Tran, Sally M.; Moos, Philip J.; Boucher, Kenneth M.; Gerads, Russell; Florell, Scott R.; Grossman, Douglas; Leachman, Sancy.

In: Nutrients, Vol. 5, No. 3, 07.03.2013, p. 725-749.

Research output: Contribution to journalArticle

Cassidy, P, Fain, HD, Cassidy, JP, Tran, SM, Moos, PJ, Boucher, KM, Gerads, R, Florell, SR, Grossman, D & Leachman, S 2013, 'Selenium for the prevention of cutaneous melanoma', Nutrients, vol. 5, no. 3, pp. 725-749. https://doi.org/10.3390/nu5030725
Cassidy P, Fain HD, Cassidy JP, Tran SM, Moos PJ, Boucher KM et al. Selenium for the prevention of cutaneous melanoma. Nutrients. 2013 Mar 7;5(3):725-749. https://doi.org/10.3390/nu5030725
Cassidy, Pamela ; Fain, Heidi D. ; Cassidy, James P. ; Tran, Sally M. ; Moos, Philip J. ; Boucher, Kenneth M. ; Gerads, Russell ; Florell, Scott R. ; Grossman, Douglas ; Leachman, Sancy. / Selenium for the prevention of cutaneous melanoma. In: Nutrients. 2013 ; Vol. 5, No. 3. pp. 725-749.
@article{9f3e4614cda6415b8ecfc6874afa6eca,
title = "Selenium for the prevention of cutaneous melanoma",
abstract = "The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process of cutaneous melanomagenisis, and to examine the utility of two different chemical forms of Se for prevention and treatment of melanoma. We studied the effects of Se in vitro on UV-induced oxidative stress in melanocytes, and on apoptosis and cell cycle progression in melanoma cells. In vivo, we used the HGF transgenic mouse model of UV-induced melanoma to demonstrate that topical treatment with L-selenomethionine results in a significant delay in the time required for UV-induced melanoma development, but also increases the rate of growth of those tumors once they appear. In a second mouse model, we found that oral administration of high dose methylseleninic acid significantly decreases the size of human melanoma xenografts. Our findings suggest that modestly elevation of selenium levels in the skin might risk acceleration of growth of incipient tumors. Additionally, certain Se compounds administered at very high doses could have utility for the treatment of fully-malignant tumors or prevention of recurrence.",
keywords = "HGF mouse, Melanoma, Methylseleninic acid, Selenium, Selenomethionine",
author = "Pamela Cassidy and Fain, {Heidi D.} and Cassidy, {James P.} and Tran, {Sally M.} and Moos, {Philip J.} and Boucher, {Kenneth M.} and Russell Gerads and Florell, {Scott R.} and Douglas Grossman and Sancy Leachman",
year = "2013",
month = "3",
day = "7",
doi = "10.3390/nu5030725",
language = "English (US)",
volume = "5",
pages = "725--749",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

TY - JOUR

T1 - Selenium for the prevention of cutaneous melanoma

AU - Cassidy, Pamela

AU - Fain, Heidi D.

AU - Cassidy, James P.

AU - Tran, Sally M.

AU - Moos, Philip J.

AU - Boucher, Kenneth M.

AU - Gerads, Russell

AU - Florell, Scott R.

AU - Grossman, Douglas

AU - Leachman, Sancy

PY - 2013/3/7

Y1 - 2013/3/7

N2 - The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process of cutaneous melanomagenisis, and to examine the utility of two different chemical forms of Se for prevention and treatment of melanoma. We studied the effects of Se in vitro on UV-induced oxidative stress in melanocytes, and on apoptosis and cell cycle progression in melanoma cells. In vivo, we used the HGF transgenic mouse model of UV-induced melanoma to demonstrate that topical treatment with L-selenomethionine results in a significant delay in the time required for UV-induced melanoma development, but also increases the rate of growth of those tumors once they appear. In a second mouse model, we found that oral administration of high dose methylseleninic acid significantly decreases the size of human melanoma xenografts. Our findings suggest that modestly elevation of selenium levels in the skin might risk acceleration of growth of incipient tumors. Additionally, certain Se compounds administered at very high doses could have utility for the treatment of fully-malignant tumors or prevention of recurrence.

AB - The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process of cutaneous melanomagenisis, and to examine the utility of two different chemical forms of Se for prevention and treatment of melanoma. We studied the effects of Se in vitro on UV-induced oxidative stress in melanocytes, and on apoptosis and cell cycle progression in melanoma cells. In vivo, we used the HGF transgenic mouse model of UV-induced melanoma to demonstrate that topical treatment with L-selenomethionine results in a significant delay in the time required for UV-induced melanoma development, but also increases the rate of growth of those tumors once they appear. In a second mouse model, we found that oral administration of high dose methylseleninic acid significantly decreases the size of human melanoma xenografts. Our findings suggest that modestly elevation of selenium levels in the skin might risk acceleration of growth of incipient tumors. Additionally, certain Se compounds administered at very high doses could have utility for the treatment of fully-malignant tumors or prevention of recurrence.

KW - HGF mouse

KW - Melanoma

KW - Methylseleninic acid

KW - Selenium

KW - Selenomethionine

UR - http://www.scopus.com/inward/record.url?scp=84875077069&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875077069&partnerID=8YFLogxK

U2 - 10.3390/nu5030725

DO - 10.3390/nu5030725

M3 - Article

C2 - 23470450

AN - SCOPUS:84875077069

VL - 5

SP - 725

EP - 749

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 3

ER -