Selective thyroid hormone receptor modulators.

Hikari A.I. Yoshihara, Thomas S. Scanlan

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Thyroid hormone regulates many important processes in vertebrates. Analysis of the symptoms that accompany hypo- and hyperthyroidism, the most common disorders of the thyroid, suggests that there are certain desirable biological effects brought about by an excess or deficiency of thyroid hormone, and that selective thyroid hormone receptor modulators (STRMs) would be potentially useful therapeutic agents. This review will provide an introduction to thyroid hormone biology, and will discuss the chemistry and pharmacology of the first generation STRMs.

Original languageEnglish (US)
Pages (from-to)1601-1616
Number of pages16
JournalCurrent topics in medicinal chemistry
Issue number14
StatePublished - 2003
Externally publishedYes

ASJC Scopus subject areas

  • Drug Discovery


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