Screening for HIV in pregnant women: Systematic review to update the 2005 U.S. Preventive Services Task Force recommendation

Roger Chou, Amy Cantor, Bernadette Zakher, Christina Bougatsos

Research output: Contribution to journalArticle

14 Scopus citations


Background: A 2005 U.S. Preventive Services Task Force (USPSTF) review found good evidence that prenatal HIV screening is accurate and can lead to interventions that reduce the risk for mother-tochild transmission. Purpose: To update the 2005 USPSTF review, focusing on previously identified research gaps and new evidence on treatments. Data Sources: MEDLINE (2004 to June 2012) and the Cochrane Library (2005 to the second quarter of 2012). Study Selection: Randomized trials and cohort studies of pregnant women on risk for mother-to-child transmission or harms associated with prenatal HIV screening or antiretroviral therapy during pregnancy. Data Extraction: 2 reviewers abstracted and confirmed study details and quality by using predefined criteria. Data Synthesis: No studies directly evaluated effects of prenatal HIV screening on risk for mother-to-child transmission or maternal or infant clinical outcomes. One fair-quality, large cohort study (HIV prevalence, 0.7%) found that rapid testing during labor was associated with a positive predictive value of 90%. New cohort studies of nonbreastfeeding women in the United States and Europe confirm that full-course combination antiretroviral therapy reduces rates of mother-to-child transmission (

Original languageEnglish (US)
Pages (from-to)719-728
Number of pages10
JournalAnnals of Internal Medicine
Issue number10
Publication statusPublished - Nov 20 2012


ASJC Scopus subject areas

  • Internal Medicine

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