Screening for Cardiac Magnetic Resonance Scar Features by 12-Lead ECG, in Patients with Preserved Ejection Fraction

Nathan Mewton, David G. Strauss, Patricia Rizzi, Richard L. Verrier, Chia Ying Liu, Larisa G. Tereshchenko, Bruce Nearing, Gustavo J. Volpe, Francis E. Marchlinski, John Moxley, Tony Killian, Katherine C. Wu, Peter Spooner, João A.C. Lima

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background Increased QRS score and wide spatial QRS-T angle are independent predictors of cardiovascular mortality in the general population. Our main objective was to assess whether a QRS score ≥5 and/or QRS-T angle ≥105 enable screening of patients for myocardial scar features. Methods Seventy-seven patients of age ≤70 years with QRS score ≥5 and/or spatial QRS-T angle ≥105 as well as left ventricular ejection fraction (LVEF) >35% were enrolled in the study. All participants underwent complete clinical examination, signal-averaged ECG (SAECG), 30-minute ambulatory ECG recording for T-wave alternans (TWA), and late gadolinium enhancement cardiac magnetic resonance (LGE-CMR). Relationship between QRS score, QRS-T angle with scar presence and pattern, as well as gray zone, core, and total scar size by LGE-CMR were assessed. Results Myocardial scar was present in 41 (53%) patients, of whom 19 (46%) exhibited a typical ischemic pattern. QRS score but not QRS-T angle was related to total scar size and gray zone size (R2 = 0.12, P = 0.002; R2 = 0.17; P ≤ 0.0001, respectively). Patients with QRS scores ≥6 had significantly greater myocardial scar and gray zone size, increased QRS duration and QRS-T angle, a higher prevalence of late potentials (LPs) presence, increased LV end-diastolic volume and decreased LVEF. There was a significant independent and positive association between TWA value and total scar (P = 0.001) and gray zone size (P = 0.01). Conclusion Patients with preserved LVEF and myocardial scar by CMR also have electrocardiographic features that could be involved in ventricular arrhythmogenesis.

Original languageEnglish (US)
Pages (from-to)49-59
Number of pages11
JournalAnnals of Noninvasive Electrocardiology
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes


  • T-wave alternans
  • death, sudden
  • magnetic resonance imaging
  • myocardial scar
  • screening

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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