Salt sensitivity: A review with a focus on non-Hispanic blacks and Hispanics

Safiya I. Richardson, Barry I. Freedman, David Ellison, Carlos J. Rodriguez

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The purpose of this review is to summarize the available information regarding salt sensitivity particularly as it relates to non-Hispanic blacks and Hispanics and to clarify possible etiologies, especially those that might shed light on potential treatment options. In non-Hispanic blacks, there is evidence that endothelial dysfunction, reduced potassium intake, decreased urinary kallikrein excretion, upregulation of sodium channel activity, dysfunction in atrial natriuretic peptide (ANP) production, and APOL1 gene nephropathy risk variants may cause or contribute to salt sensitivity. Supported treatment avenues include diets high in potassium and soybean protein, the components of which stimulate nitric oxide production. Racial heterogeneity complicates the study of salt sensitivity in Hispanic populations. Caribbean Hispanics, who have a higher proportion of African ancestry, may respond to commonly prescribed anti-hypertensive agents in a way that is characteristic of non-Hispanic black hypertensives. The low-renin hypertensive phenotype commonly seen in non-Hispanic blacks has been linked to salt sensitivity and may indicate an increased risk for salt sensitivity in a portion of the Hispanic population. In conclusion, increased morbidity and mortality associated with salt sensitivity mandates further studies evaluating the efficacy of tailored dietary and pharmacologic treatment in non-Hispanic blacks and determining the prevalence of low renin hypertension and salt sensitivity within the various subgroups of Hispanic Americans.

Original languageEnglish (US)
Pages (from-to)170-179
Number of pages10
JournalJournal of the American Society of Hypertension
Volume7
Issue number2
DOIs
StatePublished - Mar 2013

Fingerprint

Hispanic Americans
Salts
Renin
Potassium
Tissue Kallikreins
Soybean Proteins
Sodium Channels
Atrial Natriuretic Factor
Antihypertensive Agents
Population
Nitric Oxide
Up-Regulation
Therapeutics
Diet
Hypertension
Morbidity
Phenotype
Mortality
Genes

Keywords

  • Atrial natriuretic peptide
  • Hispanic
  • hypertension
  • kallikrein
  • nitric oxide
  • non-Hispanic black
  • potassium salt sensitivity
  • renal sodium channel

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Salt sensitivity : A review with a focus on non-Hispanic blacks and Hispanics. / Richardson, Safiya I.; Freedman, Barry I.; Ellison, David; Rodriguez, Carlos J.

In: Journal of the American Society of Hypertension, Vol. 7, No. 2, 03.2013, p. 170-179.

Research output: Contribution to journalArticle

Richardson, Safiya I. ; Freedman, Barry I. ; Ellison, David ; Rodriguez, Carlos J. / Salt sensitivity : A review with a focus on non-Hispanic blacks and Hispanics. In: Journal of the American Society of Hypertension. 2013 ; Vol. 7, No. 2. pp. 170-179.
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