TY - JOUR
T1 - S100 proteins as an important regulator of macrophage inflammation
AU - Xia, Chang
AU - Braunstein, Zachary
AU - Toomey, Amelia C.
AU - Zhong, Jixin
AU - Rao, Xiaoquan
N1 - Funding Information:
This work was supported by grants from National Natural and Scientific Foundation of China (81670431 and 81101247), NIH (K99ES026241 and K01DK105108), AHA (17GRNT33670485), and Natural Science Foundation of Zhejiang Province (No. Y2110580). These funding supports did not lead to any conflict of interests regarding the publication of this manuscript.
Publisher Copyright:
© 2018 Xia, Braunstein, Toomey, Zhong and Rao.
PY - 2018/1/5
Y1 - 2018/1/5
N2 - The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of intracellular and extracellular functions through regulating calcium balance, cell apoptosis, migration, proliferation, differentiation, energy metabolism, and inflammation. The intracellular functions of S100 proteins involve interaction with intracellular receptors, membrane protein recruitment/transportation, transcriptional regulation and integrating with enzymes or nucleic acids, and DNA repair. The S100 proteins could also be released from the cytoplasm, induced by tissue/cell damage and cellular stress. The extracellular S100 proteins, serving as a danger signal, are crucial in regulating immune homeostasis, post-traumatic injury, and inflammation. Extracellular S100 proteins are also considered biomarkers for some specific diseases. In this review, we will discuss the multi-functional roles of S100 proteins, especially their potential roles associated with cell migration, differentiation, tissue repair, and inflammation.
AB - The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of intracellular and extracellular functions through regulating calcium balance, cell apoptosis, migration, proliferation, differentiation, energy metabolism, and inflammation. The intracellular functions of S100 proteins involve interaction with intracellular receptors, membrane protein recruitment/transportation, transcriptional regulation and integrating with enzymes or nucleic acids, and DNA repair. The S100 proteins could also be released from the cytoplasm, induced by tissue/cell damage and cellular stress. The extracellular S100 proteins, serving as a danger signal, are crucial in regulating immune homeostasis, post-traumatic injury, and inflammation. Extracellular S100 proteins are also considered biomarkers for some specific diseases. In this review, we will discuss the multi-functional roles of S100 proteins, especially their potential roles associated with cell migration, differentiation, tissue repair, and inflammation.
KW - Biomarkers
KW - Inflammation
KW - Inflammatory disease
KW - Macrophages
KW - S100 proteins
KW - Tissue repair
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U2 - 10.3389/fimmu.2017.01908
DO - 10.3389/fimmu.2017.01908
M3 - Review article
AN - SCOPUS:85040055320
VL - 8
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - JAN
M1 - 1908
ER -