TY - JOUR
T1 - Role of the circadian system in cardiovascular disease
AU - Thosar, Saurabh S.
AU - Butler, Matthew P.
AU - Shea, Steven A.
N1 - Funding Information:
The authors acknowledge funding from the National Space Biomedical Research Institute through NCC 9-58; NIH grants R01HL125893, R01HL140577, R01HL142064, R21HL140377, and F32HL131308; the Oregon Institute of Occupational Health Sciences; the Medical Research Foundation of Oregon; and the American Sleep Medicine Foundation.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - All species organize behaviors to optimally match daily changes in the environment, leading to pronounced activity/rest cycles that track the light/dark cycle. Endogenous, approximately 24-hour circadian rhythms in the brain, autonomic nervous system, heart, and vasculature prepare the cardiovascular system for optimal function during these anticipated behavioral cycles. Cardiovascular circadian rhythms, however, may be a double-edged sword. The normal amplified responses in the morning may aid the transition from sleep to activity, but such exaggerated responses are potentially perilous in individuals susceptible to adverse cardiovascular events. Indeed, the occurrence of stroke, myocardial infarction, and sudden cardiac death all have daily patterns, striking most frequently in the morning. Furthermore, chronic disruptions of the circadian clock, as with night-shift work, contribute to increased cardiovascular risk. Here we highlight the importance of the circadian system to normal cardiovascular function and to cardiovascular disease, and identify opportunities for optimizing timing of medications in cardiovascular disease.
AB - All species organize behaviors to optimally match daily changes in the environment, leading to pronounced activity/rest cycles that track the light/dark cycle. Endogenous, approximately 24-hour circadian rhythms in the brain, autonomic nervous system, heart, and vasculature prepare the cardiovascular system for optimal function during these anticipated behavioral cycles. Cardiovascular circadian rhythms, however, may be a double-edged sword. The normal amplified responses in the morning may aid the transition from sleep to activity, but such exaggerated responses are potentially perilous in individuals susceptible to adverse cardiovascular events. Indeed, the occurrence of stroke, myocardial infarction, and sudden cardiac death all have daily patterns, striking most frequently in the morning. Furthermore, chronic disruptions of the circadian clock, as with night-shift work, contribute to increased cardiovascular risk. Here we highlight the importance of the circadian system to normal cardiovascular function and to cardiovascular disease, and identify opportunities for optimizing timing of medications in cardiovascular disease.
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U2 - 10.1172/JCI80590
DO - 10.1172/JCI80590
M3 - Review article
C2 - 29856365
AN - SCOPUS:85048277351
SN - 0021-9738
VL - 128
SP - 2157
EP - 2167
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 6
ER -