Role of neurotrophic factors in early ovarian development

Gregory Dissen, Cecilia Garcia-Rudaz, Sergio Ojeda

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Abstract

    Much is known about the endocrine hormonal mechanisms controlling ovarian development. More recently, attention has focused on identifying regulatory pathways that, operating within the ovarian microenvironment, contribute to the acquisition of ovarian reproductive competence. Within this framework, the concept has developed that neuro-trophins (NTs) and their Trk tyrosine kinase receptors, long thought to be exclusively required for the development of the nervous system, are also involved in the control of ovarian maturation. The ovary of several species, including rodents, sheep, cows, nonhu- man primates, and humans, produce NTs and express both the high-affinity receptors and the common p75 NTR receptor required for signaling. Studies in humans and rodents have shown that this expression is initiated during fetal life, before the formation of primordial follicles. Gene targeting approaches have identified TrkB, the high-affinity receptor for neurotrophin-4/5 and brain-derived neurotrophic factor, as a signaling module required for follicular assembly, early follicular growth, and oocyte survival. A similar approach has shown that nerve growth factor contributes independently to the growth of primordial follicles into gonadotropin-responsive structures. Altogether, these observations indicate that NTs are important contributors to the gonadotropin-independent process underlying the formation and initiation of ovarian follicular growth.

    Original languageEnglish (US)
    Pages (from-to)24-31
    Number of pages8
    JournalSeminars in Reproductive Medicine
    Volume27
    Issue number1
    DOIs
    StatePublished - Jan 2009

    Fingerprint

    Nerve Growth Factors
    Gonadotropins
    Rodentia
    Growth
    Gene Targeting
    Brain-Derived Neurotrophic Factor
    Receptor Protein-Tyrosine Kinases
    Nerve Growth Factor
    Mental Competency
    Primates
    Nervous System
    Oocytes
    Ovary
    Sheep

    Keywords

    • Early follicle growth
    • Neurotrophins
    • Oocyte survival
    • Ovarian folliculogenesis

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism
    • Physiology (medical)
    • Obstetrics and Gynecology
    • Reproductive Medicine

    Cite this

    Role of neurotrophic factors in early ovarian development. / Dissen, Gregory; Garcia-Rudaz, Cecilia; Ojeda, Sergio.

    In: Seminars in Reproductive Medicine, Vol. 27, No. 1, 01.2009, p. 24-31.

    Research output: Contribution to journalArticle

    Dissen, Gregory ; Garcia-Rudaz, Cecilia ; Ojeda, Sergio. / Role of neurotrophic factors in early ovarian development. In: Seminars in Reproductive Medicine. 2009 ; Vol. 27, No. 1. pp. 24-31.
    @article{095c79f50ff4439c9f8708adf73170d3,
    title = "Role of neurotrophic factors in early ovarian development",
    abstract = "Much is known about the endocrine hormonal mechanisms controlling ovarian development. More recently, attention has focused on identifying regulatory pathways that, operating within the ovarian microenvironment, contribute to the acquisition of ovarian reproductive competence. Within this framework, the concept has developed that neuro-trophins (NTs) and their Trk tyrosine kinase receptors, long thought to be exclusively required for the development of the nervous system, are also involved in the control of ovarian maturation. The ovary of several species, including rodents, sheep, cows, nonhu- man primates, and humans, produce NTs and express both the high-affinity receptors and the common p75 NTR receptor required for signaling. Studies in humans and rodents have shown that this expression is initiated during fetal life, before the formation of primordial follicles. Gene targeting approaches have identified TrkB, the high-affinity receptor for neurotrophin-4/5 and brain-derived neurotrophic factor, as a signaling module required for follicular assembly, early follicular growth, and oocyte survival. A similar approach has shown that nerve growth factor contributes independently to the growth of primordial follicles into gonadotropin-responsive structures. Altogether, these observations indicate that NTs are important contributors to the gonadotropin-independent process underlying the formation and initiation of ovarian follicular growth.",
    keywords = "Early follicle growth, Neurotrophins, Oocyte survival, Ovarian folliculogenesis",
    author = "Gregory Dissen and Cecilia Garcia-Rudaz and Sergio Ojeda",
    year = "2009",
    month = "1",
    doi = "10.1055/s-0028-1108007",
    language = "English (US)",
    volume = "27",
    pages = "24--31",
    journal = "Seminars in Reproductive Medicine",
    issn = "1526-8004",
    publisher = "Thieme Medical Publishers",
    number = "1",

    }

    TY - JOUR

    T1 - Role of neurotrophic factors in early ovarian development

    AU - Dissen, Gregory

    AU - Garcia-Rudaz, Cecilia

    AU - Ojeda, Sergio

    PY - 2009/1

    Y1 - 2009/1

    N2 - Much is known about the endocrine hormonal mechanisms controlling ovarian development. More recently, attention has focused on identifying regulatory pathways that, operating within the ovarian microenvironment, contribute to the acquisition of ovarian reproductive competence. Within this framework, the concept has developed that neuro-trophins (NTs) and their Trk tyrosine kinase receptors, long thought to be exclusively required for the development of the nervous system, are also involved in the control of ovarian maturation. The ovary of several species, including rodents, sheep, cows, nonhu- man primates, and humans, produce NTs and express both the high-affinity receptors and the common p75 NTR receptor required for signaling. Studies in humans and rodents have shown that this expression is initiated during fetal life, before the formation of primordial follicles. Gene targeting approaches have identified TrkB, the high-affinity receptor for neurotrophin-4/5 and brain-derived neurotrophic factor, as a signaling module required for follicular assembly, early follicular growth, and oocyte survival. A similar approach has shown that nerve growth factor contributes independently to the growth of primordial follicles into gonadotropin-responsive structures. Altogether, these observations indicate that NTs are important contributors to the gonadotropin-independent process underlying the formation and initiation of ovarian follicular growth.

    AB - Much is known about the endocrine hormonal mechanisms controlling ovarian development. More recently, attention has focused on identifying regulatory pathways that, operating within the ovarian microenvironment, contribute to the acquisition of ovarian reproductive competence. Within this framework, the concept has developed that neuro-trophins (NTs) and their Trk tyrosine kinase receptors, long thought to be exclusively required for the development of the nervous system, are also involved in the control of ovarian maturation. The ovary of several species, including rodents, sheep, cows, nonhu- man primates, and humans, produce NTs and express both the high-affinity receptors and the common p75 NTR receptor required for signaling. Studies in humans and rodents have shown that this expression is initiated during fetal life, before the formation of primordial follicles. Gene targeting approaches have identified TrkB, the high-affinity receptor for neurotrophin-4/5 and brain-derived neurotrophic factor, as a signaling module required for follicular assembly, early follicular growth, and oocyte survival. A similar approach has shown that nerve growth factor contributes independently to the growth of primordial follicles into gonadotropin-responsive structures. Altogether, these observations indicate that NTs are important contributors to the gonadotropin-independent process underlying the formation and initiation of ovarian follicular growth.

    KW - Early follicle growth

    KW - Neurotrophins

    KW - Oocyte survival

    KW - Ovarian folliculogenesis

    UR - http://www.scopus.com/inward/record.url?scp=61449162239&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=61449162239&partnerID=8YFLogxK

    U2 - 10.1055/s-0028-1108007

    DO - 10.1055/s-0028-1108007

    M3 - Article

    VL - 27

    SP - 24

    EP - 31

    JO - Seminars in Reproductive Medicine

    JF - Seminars in Reproductive Medicine

    SN - 1526-8004

    IS - 1

    ER -