Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography

Shaohua Pi, Acner Camino, Xiang Wei, Joseph Simonett, William Cepurna, David Huang, John Morrison, Jia Yali

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Visible light optical coherence tomography (vis-OCT) is an emerging label-free and high-resolution 3-dimensional imaging technique that can provide retinal oximetry, angiography, and flowmetry in one modality. In this paper, we studied the organization of the arterial and venous retinal circulation in rats using vis-OCT. Arterioles were found predominantly in the superficial vascular plexus whereas veins tended to drain capillaries from the deep capillary plexus. After that, we determined the oxygen metabolic rate supported by retinal microcirculation by combining retinal vessel oxygen saturation and blood flow measurements. The ability to visualize and monitor retinal circulation organization and oxygen metabolism by vis-OCT may provide new opportunities for understanding the pathology of ocular diseases.

Original languageEnglish (US)
Article number#345706
Pages (from-to)5851-5862
Number of pages12
JournalBiomedical Optics Express
Volume9
Issue number11
DOIs
StatePublished - Nov 1 2018

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oxygen metabolism
rodents
Optical Coherence Tomography
metabolism
Rodentia
tomography
Oxygen
Light
arterioles
oximetry
Retinal Vessels
Oximetry
Eye Diseases
Rheology
angiography
flow measurement
pathology
Arterioles
oxygen
Microcirculation

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography. / Pi, Shaohua; Camino, Acner; Wei, Xiang; Simonett, Joseph; Cepurna, William; Huang, David; Morrison, John; Yali, Jia.

In: Biomedical Optics Express, Vol. 9, No. 11, #345706, 01.11.2018, p. 5851-5862.

Research output: Contribution to journalArticle

Pi, Shaohua ; Camino, Acner ; Wei, Xiang ; Simonett, Joseph ; Cepurna, William ; Huang, David ; Morrison, John ; Yali, Jia. / Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography. In: Biomedical Optics Express. 2018 ; Vol. 9, No. 11. pp. 5851-5862.
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