RNA localization in Xenopus oocytes

Bruce J. Schnapp, Eric A. Arn, James O. Deshler, Martin I. Highett

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The transport and localization of mRNAs within Xenopus oocytes contributes to an asymmetry that determines axis formation in the embryo. Several mRNAs become localized along the animal-vegetal axis. The mitochondrial cloud, a specialized cytoplasmic compartment which contributes to the formation of germ plasm, and the endoplasmic reticulum play important roles in sorting and localizing these RNAs. As in other species and cell types, the localization of RNAs in Xenopus oocytes is directed by signals in the 3′ untranslated regions of the transcripts. Cytoplasmic proteins that interact with these signals are being identified, as are the links between RNA localization, intracellular organelles and early embryonic development.

Original languageEnglish (US)
Pages (from-to)529-540
Number of pages12
JournalSeminars in Cell and Developmental Biology
Volume8
Issue number6
DOIs
StatePublished - Dec 1997

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Keywords

  • 3′untranslated region
  • Cell polarity
  • Development
  • Endoplasmic reticulum

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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