RNA localization in Xenopus oocytes

Bruce Schnapp, Eric A. Arn, James O. Deshler, Martin I. Highett

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The transport and localization of mRNAs within Xenopus oocytes contributes to an asymmetry that determines axis formation in the embryo. Several mRNAs become localized along the animal-vegetal axis. The mitochondrial cloud, a specialized cytoplasmic compartment which contributes to the formation of germ plasm, and the endoplasmic reticulum play important roles in sorting and localizing these RNAs. As in other species and cell types, the localization of RNAs in Xenopus oocytes is directed by signals in the 3′ untranslated regions of the transcripts. Cytoplasmic proteins that interact with these signals are being identified, as are the links between RNA localization, intracellular organelles and early embryonic development.

Original languageEnglish (US)
Pages (from-to)529-540
Number of pages12
JournalSeminars in Cell and Developmental Biology
Volume8
Issue number6
StatePublished - Dec 1997
Externally publishedYes

Fingerprint

Xenopus
Oocytes
RNA Transport
RNA
Messenger RNA
3' Untranslated Regions
Endoplasmic Reticulum
Organelles
Embryonic Development
Embryonic Structures
Proteins

Keywords

  • 3′untranslated region
  • Cell polarity
  • Development
  • Endoplasmic reticulum

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Schnapp, B., Arn, E. A., Deshler, J. O., & Highett, M. I. (1997). RNA localization in Xenopus oocytes. Seminars in Cell and Developmental Biology, 8(6), 529-540.

RNA localization in Xenopus oocytes. / Schnapp, Bruce; Arn, Eric A.; Deshler, James O.; Highett, Martin I.

In: Seminars in Cell and Developmental Biology, Vol. 8, No. 6, 12.1997, p. 529-540.

Research output: Contribution to journalArticle

Schnapp, B, Arn, EA, Deshler, JO & Highett, MI 1997, 'RNA localization in Xenopus oocytes', Seminars in Cell and Developmental Biology, vol. 8, no. 6, pp. 529-540.
Schnapp B, Arn EA, Deshler JO, Highett MI. RNA localization in Xenopus oocytes. Seminars in Cell and Developmental Biology. 1997 Dec;8(6):529-540.
Schnapp, Bruce ; Arn, Eric A. ; Deshler, James O. ; Highett, Martin I. / RNA localization in Xenopus oocytes. In: Seminars in Cell and Developmental Biology. 1997 ; Vol. 8, No. 6. pp. 529-540.
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