Risk factors for retinopathy of prematurity: insights from outlier infants

Alexander D. Port, R. V Paul Chan, Susan Ostmo, Dongseok Choi, Michael Chiang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose: To investigate the characteristics of outlier infants for insights into ROP risk. Methods: Chart data were collected from 1,354 infants screened for ROP at Weill Cornell Medical Center and Columbia University Medical Center. ROP exam results and clinical risk factors were recorded. The cohort was stratified by weight, highest ROP stage, and need for ROP treatment. Descriptive and correlational statistics were performed. Results: For the overall cohort, regression analysis found that birth weight (OR: 0.741 per 100 g; 95 % CI: 0.606, 0.905), gestational age at birth (OR: 0.563 per week; 95 % CI: 0.454, 0.697), multiple gestation (OR 2.02, 95 % CI: 1.15, 3.56), bronchopulmonary dysplasia (OR: 4.68, 95 % CI: 1.93, 11.35), and necrotizing enterocolitis (OR 2.80, 95 % CI: 1.40, 5.16) were independent risk factors for treatment-requiring ROP. Black race was found to be a protective factor for treatment-requiring ROP (OR 0.244, 95 % CI: 0.095, 0.626). Among 15 infants with BW 1500 g, the 17 (9 %) with ROP only differed from the 166 (91 %) without ROP with respect to a higher incidence of necrotizing enterocolitis among those with ROP (11.8 % vs 0 %). Conclusions: Although known clinical risk factors were predictive of ROP stage and need for laser treatment in this cohort, they were not significantly associated with ROP at extremes of birth weight. This suggests that other clinical, maternal, or genetic factors may protect from or predispose to ROP.

Original languageEnglish (US)
Pages (from-to)1669-1677
Number of pages9
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume252
Issue number10
DOIs
StatePublished - 2014

Fingerprint

Retinopathy of Prematurity
Necrotizing Enterocolitis
Birth Weight
ROP
Bronchopulmonary Dysplasia
Therapeutics
Gestational Age

Keywords

  • Pediatric ophthalmology
  • Retina
  • Retinopathy of prematurity
  • Risk analysis

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Risk factors for retinopathy of prematurity : insights from outlier infants. / Port, Alexander D.; Chan, R. V Paul; Ostmo, Susan; Choi, Dongseok; Chiang, Michael.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 252, No. 10, 2014, p. 1669-1677.

Research output: Contribution to journalArticle

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abstract = "Purpose: To investigate the characteristics of outlier infants for insights into ROP risk. Methods: Chart data were collected from 1,354 infants screened for ROP at Weill Cornell Medical Center and Columbia University Medical Center. ROP exam results and clinical risk factors were recorded. The cohort was stratified by weight, highest ROP stage, and need for ROP treatment. Descriptive and correlational statistics were performed. Results: For the overall cohort, regression analysis found that birth weight (OR: 0.741 per 100 g; 95 {\%} CI: 0.606, 0.905), gestational age at birth (OR: 0.563 per week; 95 {\%} CI: 0.454, 0.697), multiple gestation (OR 2.02, 95 {\%} CI: 1.15, 3.56), bronchopulmonary dysplasia (OR: 4.68, 95 {\%} CI: 1.93, 11.35), and necrotizing enterocolitis (OR 2.80, 95 {\%} CI: 1.40, 5.16) were independent risk factors for treatment-requiring ROP. Black race was found to be a protective factor for treatment-requiring ROP (OR 0.244, 95 {\%} CI: 0.095, 0.626). Among 15 infants with BW 1500 g, the 17 (9 {\%}) with ROP only differed from the 166 (91 {\%}) without ROP with respect to a higher incidence of necrotizing enterocolitis among those with ROP (11.8 {\%} vs 0 {\%}). Conclusions: Although known clinical risk factors were predictive of ROP stage and need for laser treatment in this cohort, they were not significantly associated with ROP at extremes of birth weight. This suggests that other clinical, maternal, or genetic factors may protect from or predispose to ROP.",
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T2 - insights from outlier infants

AU - Port, Alexander D.

AU - Chan, R. V Paul

AU - Ostmo, Susan

AU - Choi, Dongseok

AU - Chiang, Michael

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N2 - Purpose: To investigate the characteristics of outlier infants for insights into ROP risk. Methods: Chart data were collected from 1,354 infants screened for ROP at Weill Cornell Medical Center and Columbia University Medical Center. ROP exam results and clinical risk factors were recorded. The cohort was stratified by weight, highest ROP stage, and need for ROP treatment. Descriptive and correlational statistics were performed. Results: For the overall cohort, regression analysis found that birth weight (OR: 0.741 per 100 g; 95 % CI: 0.606, 0.905), gestational age at birth (OR: 0.563 per week; 95 % CI: 0.454, 0.697), multiple gestation (OR 2.02, 95 % CI: 1.15, 3.56), bronchopulmonary dysplasia (OR: 4.68, 95 % CI: 1.93, 11.35), and necrotizing enterocolitis (OR 2.80, 95 % CI: 1.40, 5.16) were independent risk factors for treatment-requiring ROP. Black race was found to be a protective factor for treatment-requiring ROP (OR 0.244, 95 % CI: 0.095, 0.626). Among 15 infants with BW 1500 g, the 17 (9 %) with ROP only differed from the 166 (91 %) without ROP with respect to a higher incidence of necrotizing enterocolitis among those with ROP (11.8 % vs 0 %). Conclusions: Although known clinical risk factors were predictive of ROP stage and need for laser treatment in this cohort, they were not significantly associated with ROP at extremes of birth weight. This suggests that other clinical, maternal, or genetic factors may protect from or predispose to ROP.

AB - Purpose: To investigate the characteristics of outlier infants for insights into ROP risk. Methods: Chart data were collected from 1,354 infants screened for ROP at Weill Cornell Medical Center and Columbia University Medical Center. ROP exam results and clinical risk factors were recorded. The cohort was stratified by weight, highest ROP stage, and need for ROP treatment. Descriptive and correlational statistics were performed. Results: For the overall cohort, regression analysis found that birth weight (OR: 0.741 per 100 g; 95 % CI: 0.606, 0.905), gestational age at birth (OR: 0.563 per week; 95 % CI: 0.454, 0.697), multiple gestation (OR 2.02, 95 % CI: 1.15, 3.56), bronchopulmonary dysplasia (OR: 4.68, 95 % CI: 1.93, 11.35), and necrotizing enterocolitis (OR 2.80, 95 % CI: 1.40, 5.16) were independent risk factors for treatment-requiring ROP. Black race was found to be a protective factor for treatment-requiring ROP (OR 0.244, 95 % CI: 0.095, 0.626). Among 15 infants with BW 1500 g, the 17 (9 %) with ROP only differed from the 166 (91 %) without ROP with respect to a higher incidence of necrotizing enterocolitis among those with ROP (11.8 % vs 0 %). Conclusions: Although known clinical risk factors were predictive of ROP stage and need for laser treatment in this cohort, they were not significantly associated with ROP at extremes of birth weight. This suggests that other clinical, maternal, or genetic factors may protect from or predispose to ROP.

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KW - Retina

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KW - Risk analysis

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