Abstract
Chronic obstructive pulmonary disease (COPD) is predicted to become the third most common cause of death and disability worldwide by 2020. The prevalence of COPD defined by the lower limit of normal was estimated using high-quality spirometry in surveys of 14 populations aged ≥40 yrs. The strength and consistency of associations were assessed using random effects meta-analysis. Pack-years of smoking were associated with risk of COPD at each site. After adjusting for this effect, we still observed significant associations of COPD risk with age (OR 1.52 for a 10 yr age difference, 95% CI 1.35-1.71), body mass index in obese compared with normal weight (OR 0.50, 95% CI 0.37-0.67), level of education completed (OR 0.76, 95% CI 0.67-0.87), hospitalisation with a respiratory problem before age 10 yrs (OR 2.35, 95% CI 1.42-3.91), passive cigarette smoke exposure (OR 1.24, 95% CI 1.05-1.47), tuberculosis (OR 1.78, 95%CI 1.17-2.72) and a family history of COPD (OR 1.50, 95% CI 1.19-1.90). Although smoking is the most important risk factor for COPD, other risk factors are also important. More research is required to elucidate relevant risk factors in low- and middle-income countries where the greatest impact of COPD will occur. Copyright
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1343-1353 |
| Number of pages | 11 |
| Journal | European Respiratory Journal |
| Volume | 39 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2012 |
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Keywords
- Age
- Chronic obstructive pulmonary disease
- Early life
- Risk factor
- Smoking
- Tuberculosis
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Risk factors for COPD spirometrically defined from the lower limit of normal in the BOLD project. / Hooper, Richard; Burney, Peter; Vollmer, William M.; McBurnie, Mary Ann; Gislason, Thorarinn; Tan, Wan C.; Jithoo, Anamika; Kocabas, Ali; Weltee, Tobias; Buist, A (Sonia).
In: European Respiratory Journal, Vol. 39, No. 6, 01.06.2012, p. 1343-1353.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk factors for COPD spirometrically defined from the lower limit of normal in the BOLD project
AU - Hooper, Richard
AU - Burney, Peter
AU - Vollmer, William M.
AU - McBurnie, Mary Ann
AU - Gislason, Thorarinn
AU - Tan, Wan C.
AU - Jithoo, Anamika
AU - Kocabas, Ali
AU - Weltee, Tobias
AU - Buist, A (Sonia)
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Chronic obstructive pulmonary disease (COPD) is predicted to become the third most common cause of death and disability worldwide by 2020. The prevalence of COPD defined by the lower limit of normal was estimated using high-quality spirometry in surveys of 14 populations aged ≥40 yrs. The strength and consistency of associations were assessed using random effects meta-analysis. Pack-years of smoking were associated with risk of COPD at each site. After adjusting for this effect, we still observed significant associations of COPD risk with age (OR 1.52 for a 10 yr age difference, 95% CI 1.35-1.71), body mass index in obese compared with normal weight (OR 0.50, 95% CI 0.37-0.67), level of education completed (OR 0.76, 95% CI 0.67-0.87), hospitalisation with a respiratory problem before age 10 yrs (OR 2.35, 95% CI 1.42-3.91), passive cigarette smoke exposure (OR 1.24, 95% CI 1.05-1.47), tuberculosis (OR 1.78, 95%CI 1.17-2.72) and a family history of COPD (OR 1.50, 95% CI 1.19-1.90). Although smoking is the most important risk factor for COPD, other risk factors are also important. More research is required to elucidate relevant risk factors in low- and middle-income countries where the greatest impact of COPD will occur. Copyright
AB - Chronic obstructive pulmonary disease (COPD) is predicted to become the third most common cause of death and disability worldwide by 2020. The prevalence of COPD defined by the lower limit of normal was estimated using high-quality spirometry in surveys of 14 populations aged ≥40 yrs. The strength and consistency of associations were assessed using random effects meta-analysis. Pack-years of smoking were associated with risk of COPD at each site. After adjusting for this effect, we still observed significant associations of COPD risk with age (OR 1.52 for a 10 yr age difference, 95% CI 1.35-1.71), body mass index in obese compared with normal weight (OR 0.50, 95% CI 0.37-0.67), level of education completed (OR 0.76, 95% CI 0.67-0.87), hospitalisation with a respiratory problem before age 10 yrs (OR 2.35, 95% CI 1.42-3.91), passive cigarette smoke exposure (OR 1.24, 95% CI 1.05-1.47), tuberculosis (OR 1.78, 95%CI 1.17-2.72) and a family history of COPD (OR 1.50, 95% CI 1.19-1.90). Although smoking is the most important risk factor for COPD, other risk factors are also important. More research is required to elucidate relevant risk factors in low- and middle-income countries where the greatest impact of COPD will occur. Copyright
KW - Age
KW - Chronic obstructive pulmonary disease
KW - Early life
KW - Risk factor
KW - Smoking
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=84861888193&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861888193&partnerID=8YFLogxK
U2 - 10.1183/09031936.00002711
DO - 10.1183/09031936.00002711
M3 - Article
C2 - 22183479
AN - SCOPUS:84861888193
VL - 39
SP - 1343
EP - 1353
JO - European Respiratory Journal, Supplement
JF - European Respiratory Journal, Supplement
SN - 0903-1936
IS - 6
ER -