RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. SipesB. Wall, D. K. Wilcox

Research output: Contribution to journalShort survey

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Original languageEnglish (US)
Pages (from-to)S11-S24
JournalFood and Chemical Toxicology
Volume97
DOIs
StatePublished - Nov 1 2016

Keywords

  • Environmental safety
  • Genotoxicity
  • Local respiratory toxicity
  • Phototoxicity and photoallergenicity
  • Repeated dose
  • Skin sensitization
  • developmental and reproductive toxicity

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Fingerprint Dive into the research topics of 'RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0'. Together they form a unique fingerprint.

  • Cite this

    Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Miyachi, Y., Politano, V. T., Ritacco, G., Salvito, D., Schultz, T. W., Shen, J., ... Wilcox, D. K. (2016). RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0. Food and Chemical Toxicology, 97, S11-S24. https://doi.org/10.1016/j.fct.2015.12.014