RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, Allison Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. SipesB. Wall, D. K. Wilcox

Research output: Contribution to journalShort survey

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.

Original languageEnglish (US)
Pages (from-to)S101-S109
JournalFood and Chemical Toxicology
Volume97
DOIs
StatePublished - Nov 1 2016

Fingerprint

Phototoxic Dermatitis
Fragrances
safety assessment
Registries
ingredients
odors
Safety
Toxicity
Skin
Toxicology
endpoints
phototoxicity
developmental toxicity
toxicity
reproductive toxicology
genotoxicity
dosage
acetyl methyl tetramethyl tetralin

Keywords

  • Developmental and reproductive toxicity
  • Environmental safety
  • Genotoxicity
  • Local respiratory toxicity
  • Phototoxicity/photoallergenicity
  • Repeated dose
  • Skin sensitization

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8. / Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M.; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, Allison; Kromidas, L.; La Cava, S.; Lalko, J. F.; Lapczynski, A.; Liebler, D. C.; Miyachi, Y.; Politano, V. T.; Ritacco, G.; Salvito, D.; Schultz, T. W.; Shen, J.; Sipes, I. G.; Wall, B.; Wilcox, D. K.

In: Food and Chemical Toxicology, Vol. 97, 01.11.2016, p. S101-S109.

Research output: Contribution to journalShort survey

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, A, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Miyachi, Y, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2016, 'RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8', Food and Chemical Toxicology, vol. 97, pp. S101-S109. https://doi.org/10.1016/j.fct.2016.07.031
Api, A. M. ; Belsito, D. ; Bhatia, S. ; Bruze, M. ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Fryer, Allison ; Kromidas, L. ; La Cava, S. ; Lalko, J. F. ; Lapczynski, A. ; Liebler, D. C. ; Miyachi, Y. ; Politano, V. T. ; Ritacco, G. ; Salvito, D. ; Schultz, T. W. ; Shen, J. ; Sipes, I. G. ; Wall, B. ; Wilcox, D. K. / RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8. In: Food and Chemical Toxicology. 2016 ; Vol. 97. pp. S101-S109.
@article{a5572b899b0540388874667514919ac1,
title = "RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8",
abstract = "The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.",
keywords = "Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization",
author = "Api, {A. M.} and D. Belsito and S. Bhatia and M. Bruze and P. Calow and Dagli, {M. L.} and W. Dekant and Allison Fryer and L. Kromidas and {La Cava}, S. and Lalko, {J. F.} and A. Lapczynski and Liebler, {D. C.} and Y. Miyachi and Politano, {V. T.} and G. Ritacco and D. Salvito and Schultz, {T. W.} and J. Shen and Sipes, {I. G.} and B. Wall and Wilcox, {D. K.}",
year = "2016",
month = "11",
day = "1",
doi = "10.1016/j.fct.2016.07.031",
language = "English (US)",
volume = "97",
pages = "S101--S109",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8

AU - Api, A. M.

AU - Belsito, D.

AU - Bhatia, S.

AU - Bruze, M.

AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Fryer, Allison

AU - Kromidas, L.

AU - La Cava, S.

AU - Lalko, J. F.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - Miyachi, Y.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Shen, J.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.

AB - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.

KW - Developmental and reproductive toxicity

KW - Environmental safety

KW - Genotoxicity

KW - Local respiratory toxicity

KW - Phototoxicity/photoallergenicity

KW - Repeated dose

KW - Skin sensitization

UR - http://www.scopus.com/inward/record.url?scp=84997272193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84997272193&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2016.07.031

DO - 10.1016/j.fct.2016.07.031

M3 - Short survey

C2 - 27475045

AN - SCOPUS:84997272193

VL - 97

SP - S101-S109

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -