Ricin and Shiga toxins: Effects on host cell Signal transduction

Dakshina M. Jandhyala, Cheleste M. Thorpe, Bruce Magun

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Shiga toxins and ricin are potent inhibitors of protein synthesis. In addition to causing inhibition of protein synthesis, these toxins activate proinflammatory signaling cascades that may contribute to the severe diseases associated with toxin exposure. Treatment of cells with Shiga toxins and ricin have been shown to activate a number of signaling pathways including those associated with the ribotoxic stress response, Nuclear factor kappa B activation, inflammasome activation, the unfolded protein response, mTOR signaling, hemostasis, and retrograde trafficking. In this chapter, we review our current understanding of these signaling pathways as they pertain to intoxication by Shiga toxins and ricin.

Original languageEnglish (US)
Pages (from-to)41-65
Number of pages25
JournalCurrent Topics in Microbiology and Immunology
Volume357
DOIs
Publication statusPublished - 2012

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology

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