Ricin and Shiga toxins

Effects on host cell Signal transduction

Dakshina M. Jandhyala, Cheleste M. Thorpe, Bruce Magun

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Shiga toxins and ricin are potent inhibitors of protein synthesis. In addition to causing inhibition of protein synthesis, these toxins activate proinflammatory signaling cascades that may contribute to the severe diseases associated with toxin exposure. Treatment of cells with Shiga toxins and ricin have been shown to activate a number of signaling pathways including those associated with the ribotoxic stress response, Nuclear factor kappa B activation, inflammasome activation, the unfolded protein response, mTOR signaling, hemostasis, and retrograde trafficking. In this chapter, we review our current understanding of these signaling pathways as they pertain to intoxication by Shiga toxins and ricin.

Original languageEnglish (US)
Pages (from-to)41-65
Number of pages25
JournalCurrent Topics in Microbiology and Immunology
Volume357
DOIs
StatePublished - 2012

Fingerprint

Shiga Toxins
Ricin
Signal Transduction
Inflammasomes
Unfolded Protein Response
Protein Synthesis Inhibitors
NF-kappa B
Hemostasis
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology

Cite this

Ricin and Shiga toxins : Effects on host cell Signal transduction. / Jandhyala, Dakshina M.; Thorpe, Cheleste M.; Magun, Bruce.

In: Current Topics in Microbiology and Immunology, Vol. 357, 2012, p. 41-65.

Research output: Contribution to journalArticle

Jandhyala, Dakshina M. ; Thorpe, Cheleste M. ; Magun, Bruce. / Ricin and Shiga toxins : Effects on host cell Signal transduction. In: Current Topics in Microbiology and Immunology. 2012 ; Vol. 357. pp. 41-65.
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