Ricin and Shiga toxins: Effects on host cell Signal transduction

Dakshina M. Jandhyala, Cheleste M. Thorpe, Bruce Magun

Research output: Chapter in Book/Report/Conference proceedingChapter

29 Scopus citations

Abstract

Shiga toxins and ricin are potent inhibitors of protein synthesis. In addition to causing inhibition of protein synthesis, these toxins activate proinflammatory signaling cascades that may contribute to the severe diseases associated with toxin exposure. Treatment of cells with Shiga toxins and ricin have been shown to activate a number of signaling pathways including those associated with the ribotoxic stress response, Nuclear factor kappa B activation, inflammasome activation, the unfolded protein response, mTOR signaling, hemostasis, and retrograde trafficking. In this chapter, we review our current understanding of these signaling pathways as they pertain to intoxication by Shiga toxins and ricin.

Original languageEnglish (US)
Title of host publicationRicin and Shiga Toxins
Subtitle of host publicationPathogenesis, Immunity, Vaccines and Therapeutics
EditorsNicholas Mantis, Nicholas Mantis
Pages41-65
Number of pages25
DOIs
StatePublished - Mar 12 2012

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume357
ISSN (Print)0070-217X

    Fingerprint

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Jandhyala, D. M., Thorpe, C. M., & Magun, B. (2012). Ricin and Shiga toxins: Effects on host cell Signal transduction. In N. Mantis, & N. Mantis (Eds.), Ricin and Shiga Toxins: Pathogenesis, Immunity, Vaccines and Therapeutics (pp. 41-65). (Current Topics in Microbiology and Immunology; Vol. 357). https://doi.org/10.1007/82_2011_181