Ricin and Shiga toxins: Effects on host cell Signal transduction

Dakshina M. Jandhyala, Cheleste M. Thorpe, Bruce Magun

    Research output: Chapter in Book/Report/Conference proceedingChapter

    33 Scopus citations

    Abstract

    Shiga toxins and ricin are potent inhibitors of protein synthesis. In addition to causing inhibition of protein synthesis, these toxins activate proinflammatory signaling cascades that may contribute to the severe diseases associated with toxin exposure. Treatment of cells with Shiga toxins and ricin have been shown to activate a number of signaling pathways including those associated with the ribotoxic stress response, Nuclear factor kappa B activation, inflammasome activation, the unfolded protein response, mTOR signaling, hemostasis, and retrograde trafficking. In this chapter, we review our current understanding of these signaling pathways as they pertain to intoxication by Shiga toxins and ricin.

    Original languageEnglish (US)
    Title of host publicationRicin and Shiga Toxins
    Subtitle of host publicationPathogenesis, Immunity, Vaccines and Therapeutics
    EditorsNicholas Mantis, Nicholas Mantis
    Pages41-65
    Number of pages25
    DOIs
    StatePublished - 2012

    Publication series

    NameCurrent Topics in Microbiology and Immunology
    Volume357
    ISSN (Print)0070-217X

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Microbiology
    • Immunology
    • Microbiology (medical)

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