Rho GTPases in platelet function

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The Rho family of GTP binding proteins, also commonly referred to as the Rho GTPases, are master regulators of the platelet cytoskeleton and platelet function. These low-molecular-weight or 'small' GTPases act as signaling switches in the spatial and temporal transduction, and amplification of signals from platelet cell surface receptors to the intracellular signaling pathways that drive platelet function. The Rho GTPase family members RhoA, Cdc42 and Rac1 have emerged as key regulators in the dynamics of the actin cytoskeleton in platelets and play key roles in platelet aggregation, secretion, spreading and thrombus formation. Rho GTPase regulators, including GEFs and GAPs and downstream effectors, such as the WASPs, formins and PAKs, may also regulate platelet activation and function. In this review, we provide an overview of Rho GTPase signaling in platelet physiology. Previous studies of Rho GTPases and platelets have had a shared history, as platelets have served as an ideal, non-transformed cellular model to characterize Rho function. Likewise, recent studies of the cell biology of Rho GTPase family members have helped to build an understanding of the molecular regulation of platelet function and will continue to do so through the further characterization of Rho GTPases as well as Rho GAPs, GEFs, RhoGDIs and Rho effectors in actin reorganization and other Rho-driven cellular processes.

Original languageEnglish (US)
Pages (from-to)35-46
Number of pages12
JournalJournal of Thrombosis and Haemostasis
Volume11
Issue number1
DOIs
StatePublished - Jan 2013

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rho GTP-Binding Proteins
Blood Platelets
Monomeric GTP-Binding Proteins
Platelet Activation
Cell Surface Receptors
Cytoskeleton
Actin Cytoskeleton
Platelet Aggregation
Cell Biology
Actins
Signal Transduction
Thrombosis
Molecular Weight
History

Keywords

  • Actin
  • Cdc42
  • Cytoskeleton
  • Platelet
  • Rac
  • Rho

ASJC Scopus subject areas

  • Hematology

Cite this

Rho GTPases in platelet function. / Aslan, Joseph; McCarty, Owen.

In: Journal of Thrombosis and Haemostasis, Vol. 11, No. 1, 01.2013, p. 35-46.

Research output: Contribution to journalArticle

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