Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS

Jessica Carmen, Tim Magnus, Riccardo Cassiani-Ingoni, Lawrence (Larry) Sherman, Mahendra S. Rao, Mark P. Mattson

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    The lineages of both astrocytes and oligodendrocytes have been popular areas of research in the last decade. The source of these cells in the mature CNS is relevant to the study of the cellular response to CNS injury. A significant amount of evidence exists to suggest that resident precursor cells proliferate and differentiate into mature glial cells that facilitate tissue repair and recovery. Additionally, the re-entry of mature astrocytes into the cell cycle can also contribute to the pool of new astrocytes that are observed following CNS injury. In order to better understand the glial response to injury in the adult CNS we must revisit the astrocyte-oligodendrocyte relationship. Specifically, we argue that there is a common glial precursor cell from which astrocytes and oligodendrocytes differentiate and that the microenvironment surrounding the injury determines the fate of the stimulated precursor cell. Ideally, better understanding the origin of new glial cells in the injured CNS will facilitate the development of therapeutics targeted to alter the glial response in a beneficial way.

    Original languageEnglish (US)
    Pages (from-to)151-162
    Number of pages12
    JournalProgress in Neurobiology
    Volume82
    Issue number3
    DOIs
    StatePublished - Jun 2007

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    Oligodendroglia
    Neuroglia
    Astrocytes
    Wounds and Injuries
    Cell Cycle
    Research

    Keywords

    • Astrocytes
    • CNS damage
    • CNS injury
    • Glial precursor
    • Glial scar
    • Oligodendrocytes
    • Stem cell

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS. / Carmen, Jessica; Magnus, Tim; Cassiani-Ingoni, Riccardo; Sherman, Lawrence (Larry); Rao, Mahendra S.; Mattson, Mark P.

    In: Progress in Neurobiology, Vol. 82, No. 3, 06.2007, p. 151-162.

    Research output: Contribution to journalArticle

    Carmen, J, Magnus, T, Cassiani-Ingoni, R, Sherman, LL, Rao, MS & Mattson, MP 2007, 'Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS', Progress in Neurobiology, vol. 82, no. 3, pp. 151-162. https://doi.org/10.1016/j.pneurobio.2007.03.001
    Carmen, Jessica ; Magnus, Tim ; Cassiani-Ingoni, Riccardo ; Sherman, Lawrence (Larry) ; Rao, Mahendra S. ; Mattson, Mark P. / Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS. In: Progress in Neurobiology. 2007 ; Vol. 82, No. 3. pp. 151-162.
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