Review of neurosurgical fluorescence imaging methodologies

Brian W. Pogue, Summer Gibbs, Pablo A. Valdés, Kimberley S. Samkoe, David W. Roberts, Keith D. Paulsen

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Fluorescence imaging in neurosurgery has a long historical development, with various biomarkers and biochemical agents being used, and numerous technological approaches. This review focuses on contrast agents, summarizing endogenous fluorescence, exogenously stimulated fluorescence, and exogenous contrast agents, and then on tools used for imaging. It ends with a summary of key clinical trials that lead to consensus studies. The practical utility of protoporphyrin IX (PpIX) as stimulated by administration of δ -aminolevulinic acid has had substantial pilot clinical studies and basic science research completed. Recently, multicenter clinical trials using PpIX fluorescence to guide resection have shown efficacy for improved short-term survival. Exogenous agents are being developed and tested preclinically, and hopefully hold the potential for long-term survival benefit if they provide additional capabilities for resection of microinvasive disease or certain tumor subtypes that do not produce PpIX or help delineate low-grade tumors. The range of technologies used for measurement and imaging varies widely, with most clinical trials being carried out with either point probes or modified surgical microscopes. Currently, optimized probe approaches are showing efficacy in clinical trials, and fully commercialized imaging systems are emerging, which will clearly help to lead adoption into neurosurgical practice.

Original languageEnglish (US)
Article number5437303
Pages (from-to)493-505
Number of pages13
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume16
Issue number3
DOIs
StatePublished - May 2010
Externally publishedYes

Fingerprint

Fluorescence
methodology
Imaging techniques
fluorescence
Tumors
tumors
Neurosurgery
probes
biomarkers
Biomarkers
Imaging systems
emerging
grade
Microscopes
microscopes
acids
Acids

Keywords

  • Brain tumor
  • Fluorescence
  • Glioma
  • Imaging
  • Microscopy
  • Neurosurgery
  • Protoporphyrin
  • Surgery

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

Cite this

Pogue, B. W., Gibbs, S., Valdés, P. A., Samkoe, K. S., Roberts, D. W., & Paulsen, K. D. (2010). Review of neurosurgical fluorescence imaging methodologies. IEEE Journal on Selected Topics in Quantum Electronics, 16(3), 493-505. [5437303]. https://doi.org/10.1109/JSTQE.2009.2034541

Review of neurosurgical fluorescence imaging methodologies. / Pogue, Brian W.; Gibbs, Summer; Valdés, Pablo A.; Samkoe, Kimberley S.; Roberts, David W.; Paulsen, Keith D.

In: IEEE Journal on Selected Topics in Quantum Electronics, Vol. 16, No. 3, 5437303, 05.2010, p. 493-505.

Research output: Contribution to journalArticle

Pogue, BW, Gibbs, S, Valdés, PA, Samkoe, KS, Roberts, DW & Paulsen, KD 2010, 'Review of neurosurgical fluorescence imaging methodologies', IEEE Journal on Selected Topics in Quantum Electronics, vol. 16, no. 3, 5437303, pp. 493-505. https://doi.org/10.1109/JSTQE.2009.2034541
Pogue, Brian W. ; Gibbs, Summer ; Valdés, Pablo A. ; Samkoe, Kimberley S. ; Roberts, David W. ; Paulsen, Keith D. / Review of neurosurgical fluorescence imaging methodologies. In: IEEE Journal on Selected Topics in Quantum Electronics. 2010 ; Vol. 16, No. 3. pp. 493-505.
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