Reversal of infection with Mycobacterium avium intracellulare by treatment with alpha-interferon in a patient with hairy cell leukemia

R. T. Maziarz, I. Tepler, J. H. Antin, M. A. Keroack, W. H. Churchill, W. Holmes, J. Rappeport

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A patient with debilitating hairy cell leukemia and documented Mycobacterium avium intracellulare infection unresponsive to standard antituberculous therapy who was treated with alpha-interferon is described. A rapid clinical response with correction of underlying pancytopenia and eradication of the atypical mycobacteria infection was found. No deleterious effects from alpha-interferon therapy were found. The associated resolution of anergy and the sterilization of bone marrow suggest that the reversal of host cellular immune defects led to the eventual control of this patient's infection.

Original languageEnglish (US)
Pages (from-to)292-294
Number of pages3
JournalAnnals of internal medicine
Volume109
Issue number4
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Internal Medicine

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