Reversal of infection with Mycobacterium avium intracellulare by treatment with alpha-interferon in a patient with hairy cell leukemia

Richard Maziarz, I. Tepler, J. H. Antin, M. A. Keroack, W. H. Churchill, W. Holmes, J. Rappeport

Research output: Contribution to journalArticle

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Abstract

A patient with debilitating hairy cell leukemia and documented Mycobacterium avium intracellulare infection unresponsive to standard antituberculous therapy who was treated with alpha-interferon is described. A rapid clinical response with correction of underlying pancytopenia and eradication of the atypical mycobacteria infection was found. No deleterious effects from alpha-interferon therapy were found. The associated resolution of anergy and the sterilization of bone marrow suggest that the reversal of host cellular immune defects led to the eventual control of this patient's infection.

Original languageEnglish (US)
Pages (from-to)292-294
Number of pages3
JournalAnnals of Internal Medicine
Volume109
Issue number4
StatePublished - 1988
Externally publishedYes

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Mycobacterium avium-intracellulare Infection
Hairy Cell Leukemia
Interferon-alpha
Nontuberculous Mycobacterium Infections
Pancytopenia
Infection Control
Bone Marrow
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Maziarz, R., Tepler, I., Antin, J. H., Keroack, M. A., Churchill, W. H., Holmes, W., & Rappeport, J. (1988). Reversal of infection with Mycobacterium avium intracellulare by treatment with alpha-interferon in a patient with hairy cell leukemia. Annals of Internal Medicine, 109(4), 292-294.

Reversal of infection with Mycobacterium avium intracellulare by treatment with alpha-interferon in a patient with hairy cell leukemia. / Maziarz, Richard; Tepler, I.; Antin, J. H.; Keroack, M. A.; Churchill, W. H.; Holmes, W.; Rappeport, J.

In: Annals of Internal Medicine, Vol. 109, No. 4, 1988, p. 292-294.

Research output: Contribution to journalArticle

Maziarz, R, Tepler, I, Antin, JH, Keroack, MA, Churchill, WH, Holmes, W & Rappeport, J 1988, 'Reversal of infection with Mycobacterium avium intracellulare by treatment with alpha-interferon in a patient with hairy cell leukemia', Annals of Internal Medicine, vol. 109, no. 4, pp. 292-294.
Maziarz, Richard ; Tepler, I. ; Antin, J. H. ; Keroack, M. A. ; Churchill, W. H. ; Holmes, W. ; Rappeport, J. / Reversal of infection with Mycobacterium avium intracellulare by treatment with alpha-interferon in a patient with hairy cell leukemia. In: Annals of Internal Medicine. 1988 ; Vol. 109, No. 4. pp. 292-294.
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