Retrieving common dynamics of gene regulatory networks under various perturbations

Young Hwan Chang; Roel Dobbe; Palak Bhushan; Joe W. Gray; Claire J. Tomlin

doi:10.1109/CDC.2015.7402597

Retrieving common dynamics of gene regulatory networks under various perturbations

Young Hwan Chang, Roel Dobbe, Palak Bhushan, Joe W. Gray, Claire J. Tomlin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Recently, with the growth of high-throughput proteomic data, in particular time series gene expression data from various perturbations, a general question that has arisen is how to extract meaningful structure from inherently heterogeneous data. Little is known about exactly how these gene regulatory networks (GRNs) operate under different stimuli. Challenges due to the lack of knowledge may cause bias or uncertainty in identifying parameters or inferring the GRN structure. We propose a new algorithm which enables us to estimate bias error due to the effect of perturbations, and correctly identify the common graph structure among biased inferred graph structures. To do this, we retrieve common dynamics of the GRN subject to various perturbations inspired by image repairing in computer vision [1].

Original language	English (US)
Title of host publication	54rd IEEE Conference on Decision and Control,CDC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	2531-2536
Number of pages	6
ISBN (Electronic)	9781479978861
DOIs	https://doi.org/10.1109/CDC.2015.7402597
State	Published - Feb 8 2015
Event	54th IEEE Conference on Decision and Control, CDC 2015 - Osaka, Japan Duration: Dec 15 2015 → Dec 18 2015

Publication series

Name	Proceedings of the IEEE Conference on Decision and Control
Volume	54rd IEEE Conference on Decision and Control,CDC 2015
ISSN (Print)	0743-1546
ISSN (Electronic)	2576-2370

Other

Other	54th IEEE Conference on Decision and Control, CDC 2015
Country/Territory	Japan
City	Osaka
Period	12/15/15 → 12/18/15

ASJC Scopus subject areas

Control and Systems Engineering
Modeling and Simulation
Control and Optimization

Access to Document

10.1109/CDC.2015.7402597

Cite this

Chang, Y. H., Dobbe, R., Bhushan, P., Gray, J. W., & Tomlin, C. J. (2015). Retrieving common dynamics of gene regulatory networks under various perturbations. In 54rd IEEE Conference on Decision and Control,CDC 2015 (pp. 2531-2536). Article 7402597 (Proceedings of the IEEE Conference on Decision and Control; Vol. 54rd IEEE Conference on Decision and Control,CDC 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CDC.2015.7402597

Retrieving common dynamics of gene regulatory networks under various perturbations. / Chang, Young Hwan; Dobbe, Roel; Bhushan, Palak et al.
54rd IEEE Conference on Decision and Control,CDC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 2531-2536 7402597 (Proceedings of the IEEE Conference on Decision and Control; Vol. 54rd IEEE Conference on Decision and Control,CDC 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Chang, YH, Dobbe, R, Bhushan, P, Gray, JW & Tomlin, CJ 2015, Retrieving common dynamics of gene regulatory networks under various perturbations. in 54rd IEEE Conference on Decision and Control,CDC 2015., 7402597, Proceedings of the IEEE Conference on Decision and Control, vol. 54rd IEEE Conference on Decision and Control,CDC 2015, Institute of Electrical and Electronics Engineers Inc., pp. 2531-2536, 54th IEEE Conference on Decision and Control, CDC 2015, Osaka, Japan, 12/15/15. https://doi.org/10.1109/CDC.2015.7402597

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Retrieving common dynamics of gene regulatory networks under various perturbations

Abstract

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