Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins

Seung Whan Kim, Han Jong Kim, Dong Ju Jung, Soo-Kyung Lee, Youn Sung Kim, Jae Hong Kim, Tae Sung Kim, Jae Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF.

Original languageEnglish (US)
Pages (from-to)6638-6642
Number of pages5
JournalOncogene
Volume20
Issue number45
DOIs
StatePublished - Oct 4 2001
Externally publishedYes

Fingerprint

Serum Response Factor
Retinoids
Transcriptional Activation
Proteins
Transcription Factors
Retinoid X Receptors
Cytoplasmic and Nuclear Receptors
Tretinoin
DNA

Keywords

  • Coactivator
  • Nuclear receptors
  • Retinoids
  • SRF
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins. / Kim, Seung Whan; Kim, Han Jong; Jung, Dong Ju; Lee, Soo-Kyung; Kim, Youn Sung; Kim, Jae Hong; Kim, Tae Sung; Lee, Jae.

In: Oncogene, Vol. 20, No. 45, 04.10.2001, p. 6638-6642.

Research output: Contribution to journalArticle

Kim, Seung Whan ; Kim, Han Jong ; Jung, Dong Ju ; Lee, Soo-Kyung ; Kim, Youn Sung ; Kim, Jae Hong ; Kim, Tae Sung ; Lee, Jae. / Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins. In: Oncogene. 2001 ; Vol. 20, No. 45. pp. 6638-6642.
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