Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins

Seung Whan Kim, Han Jong Kim, Dong Ju Jung, Soo Kyung Lee, Youn Sung Kim, Jae Hong Kim, Tae Sung Kim, Jae Woon Lee

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF.

Original languageEnglish (US)
Pages (from-to)6638-6642
Number of pages5
JournalOncogene
Volume20
Issue number45
DOIs
StatePublished - Oct 4 2001

Keywords

  • Coactivator
  • Nuclear receptors
  • Retinoids
  • SRF
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins'. Together they form a unique fingerprint.

  • Cite this