Abstract
Background and purpose: The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. Methods: Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years. Results: The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06). Conclusions: There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.
Original language | English (US) |
---|---|
Pages (from-to) | 1138-1141 |
Number of pages | 4 |
Journal | European Journal of Neurology |
Volume | 22 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2015 |
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Keywords
- Magnetic resonance imaging
- Multiple sclerosis
- Neuroprotection
- Optical coherence tomography
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Retinal axonal loss in very early stages of multiple sclerosis. / Maghzi, A. H.; Graves, J.; Revirajan, N.; Spain, Rebecca; Liu, S.; Mcculloch, C. E.; Pelletier, D.; Green, A. J.; Waubant, E.
In: European Journal of Neurology, Vol. 22, No. 7, 01.07.2015, p. 1138-1141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Retinal axonal loss in very early stages of multiple sclerosis
AU - Maghzi, A. H.
AU - Graves, J.
AU - Revirajan, N.
AU - Spain, Rebecca
AU - Liu, S.
AU - Mcculloch, C. E.
AU - Pelletier, D.
AU - Green, A. J.
AU - Waubant, E.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Background and purpose: The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. Methods: Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years. Results: The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06). Conclusions: There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.
AB - Background and purpose: The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. Methods: Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years. Results: The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06). Conclusions: There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.
KW - Magnetic resonance imaging
KW - Multiple sclerosis
KW - Neuroprotection
KW - Optical coherence tomography
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UR - http://www.scopus.com/inward/citedby.url?scp=84930759217&partnerID=8YFLogxK
U2 - 10.1111/ene.12722
DO - 10.1111/ene.12722
M3 - Article
C2 - 25929276
AN - SCOPUS:84930759217
VL - 22
SP - 1138
EP - 1141
JO - European Journal of Neurology
JF - European Journal of Neurology
SN - 1351-5101
IS - 7
ER -