Retinal axonal loss in very early stages of multiple sclerosis

A. H. Maghzi, J. Graves, N. Revirajan, Rebecca Spain, S. Liu, C. E. Mcculloch, D. Pelletier, A. J. Green, E. Waubant

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and purpose: The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. Methods: Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years. Results: The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06). Conclusions: There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.

Original languageEnglish (US)
Pages (from-to)1138-1141
Number of pages4
JournalEuropean Journal of Neurology
Volume22
Issue number7
DOIs
StatePublished - Jul 1 2015

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Multiple Sclerosis
Nerve Fibers
Atrophy
Relapsing-Remitting Multiple Sclerosis
Optical Coherence Tomography
Magnetic Resonance Imaging
Confidence Intervals
White Matter

Keywords

  • Magnetic resonance imaging
  • Multiple sclerosis
  • Neuroprotection
  • Optical coherence tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Maghzi, A. H., Graves, J., Revirajan, N., Spain, R., Liu, S., Mcculloch, C. E., ... Waubant, E. (2015). Retinal axonal loss in very early stages of multiple sclerosis. European Journal of Neurology, 22(7), 1138-1141. https://doi.org/10.1111/ene.12722

Retinal axonal loss in very early stages of multiple sclerosis. / Maghzi, A. H.; Graves, J.; Revirajan, N.; Spain, Rebecca; Liu, S.; Mcculloch, C. E.; Pelletier, D.; Green, A. J.; Waubant, E.

In: European Journal of Neurology, Vol. 22, No. 7, 01.07.2015, p. 1138-1141.

Research output: Contribution to journalArticle

Maghzi, AH, Graves, J, Revirajan, N, Spain, R, Liu, S, Mcculloch, CE, Pelletier, D, Green, AJ & Waubant, E 2015, 'Retinal axonal loss in very early stages of multiple sclerosis', European Journal of Neurology, vol. 22, no. 7, pp. 1138-1141. https://doi.org/10.1111/ene.12722
Maghzi AH, Graves J, Revirajan N, Spain R, Liu S, Mcculloch CE et al. Retinal axonal loss in very early stages of multiple sclerosis. European Journal of Neurology. 2015 Jul 1;22(7):1138-1141. https://doi.org/10.1111/ene.12722
Maghzi, A. H. ; Graves, J. ; Revirajan, N. ; Spain, Rebecca ; Liu, S. ; Mcculloch, C. E. ; Pelletier, D. ; Green, A. J. ; Waubant, E. / Retinal axonal loss in very early stages of multiple sclerosis. In: European Journal of Neurology. 2015 ; Vol. 22, No. 7. pp. 1138-1141.
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