Abstract
Background and purpose: The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. Methods: Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years. Results: The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06). Conclusions: There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1138-1141 |
| Number of pages | 4 |
| Journal | European Journal of Neurology |
| Volume | 22 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2015 |
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Keywords
- Magnetic resonance imaging
- Multiple sclerosis
- Neuroprotection
- Optical coherence tomography
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Retinal axonal loss in very early stages of multiple sclerosis. / Maghzi, A. H.; Graves, J.; Revirajan, N.; Spain, Rebecca; Liu, S.; Mcculloch, C. E.; Pelletier, D.; Green, A. J.; Waubant, E.
In: European Journal of Neurology, Vol. 22, No. 7, 01.07.2015, p. 1138-1141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Retinal axonal loss in very early stages of multiple sclerosis
AU - Maghzi, A. H.
AU - Graves, J.
AU - Revirajan, N.
AU - Spain, Rebecca
AU - Liu, S.
AU - Mcculloch, C. E.
AU - Pelletier, D.
AU - Green, A. J.
AU - Waubant, E.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Background and purpose: The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. Methods: Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years. Results: The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06). Conclusions: There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.
AB - Background and purpose: The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. Methods: Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years. Results: The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06). Conclusions: There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.
KW - Magnetic resonance imaging
KW - Multiple sclerosis
KW - Neuroprotection
KW - Optical coherence tomography
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UR - http://www.scopus.com/inward/citedby.url?scp=84930759217&partnerID=8YFLogxK
U2 - 10.1111/ene.12722
DO - 10.1111/ene.12722
M3 - Article
C2 - 25929276
AN - SCOPUS:84930759217
VL - 22
SP - 1138
EP - 1141
JO - European Journal of Neurology
JF - European Journal of Neurology
SN - 1351-5101
IS - 7
ER -