Retinal axonal loss in very early stages of multiple sclerosis

A. H. Maghzi; J. Graves; N. Revirajan; R. Spain; S. Liu; C. E. Mcculloch; D. Pelletier; A. J. Green; E. Waubant

doi:10.1111/ene.12722

Retinal axonal loss in very early stages of multiple sclerosis

A. H. Maghzi, J. Graves, N. Revirajan, R. Spain, S. Liu, C. E. Mcculloch, D. Pelletier, A. J. Green, E. Waubant

Neurology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background and purpose: The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. Methods: Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years. Results: The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06). Conclusions: There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.

Original language	English (US)
Pages (from-to)	1138-1141
Number of pages	4
Journal	European Journal of Neurology
Volume	22
Issue number	7
DOIs	https://doi.org/10.1111/ene.12722
State	Published - Jul 1 2015

Keywords

Magnetic resonance imaging
Multiple sclerosis
Neuroprotection
Optical coherence tomography

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/ene.12722

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title = "Retinal axonal loss in very early stages of multiple sclerosis",

abstract = "Background and purpose: The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. Methods: Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years. Results: The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06). Conclusions: There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.",

keywords = "Magnetic resonance imaging, Multiple sclerosis, Neuroprotection, Optical coherence tomography",

author = "Maghzi, {A. H.} and J. Graves and N. Revirajan and R. Spain and S. Liu and Mcculloch, {C. E.} and D. Pelletier and Green, {A. J.} and E. Waubant",

year = "2015",

month = jul,

day = "1",

doi = "10.1111/ene.12722",

language = "English (US)",

volume = "22",

pages = "1138--1141",

journal = "European Journal of Neurology",

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TY - JOUR

T1 - Retinal axonal loss in very early stages of multiple sclerosis

AU - Maghzi, A. H.

AU - Graves, J.

AU - Revirajan, N.

AU - Spain, R.

AU - Liu, S.

AU - Mcculloch, C. E.

AU - Pelletier, D.

AU - Green, A. J.

AU - Waubant, E.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background and purpose: The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. Methods: Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years. Results: The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06). Conclusions: There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.

AB - Background and purpose: The lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. Methods: Forty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3 years. Results: The peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2 μm (95% confidence interval -3.89, -0.11; P = 0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P = 0.08) and longitudinal analyses (P = 0.06). Conclusions: There is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.

KW - Magnetic resonance imaging

KW - Multiple sclerosis

KW - Neuroprotection

KW - Optical coherence tomography

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