Rethinking Lymphatic Vessels and Antitumor Immunity

Amanda W. Lund

doi:10.1016/j.trecan.2016.09.005

Rethinking Lymphatic Vessels and Antitumor Immunity

Amanda W. Lund

Cell Developmental and Cancer Biology

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Lymphatic vessels facilitate fluid homeostasis, immune cell trafficking, and lipid transport, and contribute to solid tumor progression as routes of metastasis. Given new evidence that lymphatic vessels both correlate with intratumoral lymphocytes and directly suppress immune function, I reevaluate the passive lymphatic vessel paradigm and discuss its relevance to antitumor immunity.

Original language	English (US)
Pages (from-to)	548-551
Number of pages	4
Journal	Trends in Cancer
Volume	2
Issue number	10
DOIs	https://doi.org/10.1016/j.trecan.2016.09.005
State	Published - Oct 1 2016

Keywords

T cells
immunotherapy
lymphatic vessels
solid tumors

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/j.trecan.2016.09.005

Cite this

@article{a961ea73b5b147fa93a9d61f9c975fa4,

title = "Rethinking Lymphatic Vessels and Antitumor Immunity",

abstract = "Lymphatic vessels facilitate fluid homeostasis, immune cell trafficking, and lipid transport, and contribute to solid tumor progression as routes of metastasis. Given new evidence that lymphatic vessels both correlate with intratumoral lymphocytes and directly suppress immune function, I reevaluate the passive lymphatic vessel paradigm and discuss its relevance to antitumor immunity.",

keywords = "T cells, immunotherapy, lymphatic vessels, solid tumors",

author = "Lund, {Amanda W.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = oct,

day = "1",

doi = "10.1016/j.trecan.2016.09.005",

language = "English (US)",

volume = "2",

pages = "548--551",

journal = "Trends in Cancer",

issn = "2405-8033",

publisher = "Cell Press",

number = "10",

}

TY - JOUR

T1 - Rethinking Lymphatic Vessels and Antitumor Immunity

AU - Lund, Amanda W.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Lymphatic vessels facilitate fluid homeostasis, immune cell trafficking, and lipid transport, and contribute to solid tumor progression as routes of metastasis. Given new evidence that lymphatic vessels both correlate with intratumoral lymphocytes and directly suppress immune function, I reevaluate the passive lymphatic vessel paradigm and discuss its relevance to antitumor immunity.

AB - Lymphatic vessels facilitate fluid homeostasis, immune cell trafficking, and lipid transport, and contribute to solid tumor progression as routes of metastasis. Given new evidence that lymphatic vessels both correlate with intratumoral lymphocytes and directly suppress immune function, I reevaluate the passive lymphatic vessel paradigm and discuss its relevance to antitumor immunity.

KW - T cells

KW - immunotherapy

KW - lymphatic vessels

KW - solid tumors

UR - http://www.scopus.com/inward/record.url?scp=84994171924&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994171924&partnerID=8YFLogxK

U2 - 10.1016/j.trecan.2016.09.005

DO - 10.1016/j.trecan.2016.09.005

M3 - Review article

C2 - 28741486

AN - SCOPUS:84994171924

SN - 2405-8033

VL - 2

SP - 548

EP - 551

JO - Trends in Cancer

JF - Trends in Cancer

IS - 10

ER -

Rethinking Lymphatic Vessels and Antitumor Immunity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this