Restoring acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses

Matthew W. Coryell, Amanda M. Wunsch, Jill M. Haenfler, Jason E. Allen, Jodi L. McBride, Beverly L. Davidson, John A. Wemmie

    Research output: Contribution to journalArticle

    57 Scopus citations

    Abstract

    Acid-sensing ion channel-1a (ASIC1a) contributes to multiple fear behaviors, however the site of ASIC1a action in behavior is not known. To explore a specific location of ASIC1a action, we expressed ASIC1a in the basolateral amygdala of ASIC1a-/- mice using viral vector-mediated gene transfer. This rescued context-dependent fear memory, but not the freezing deficit during training or the unconditioned fear response to predator odor. These data pinpoint the basolateral amygdala as the site where ASIC1a contributes to fear memory. They also discriminate fear memory from fear expressed during training and from unconditioned fear. Furthermore, this work illustrates a strategy for identifying discrete brain regions where specific genes contribute to complex behaviors.

    Original languageEnglish (US)
    Pages (from-to)13738-13741
    Number of pages4
    JournalJournal of Neuroscience
    Volume28
    Issue number51
    DOIs
    StatePublished - Dec 17 2008

    Keywords

    • ASIC1a
    • Amygdala
    • Fear conditioning
    • Region-restricted
    • Unconditioned fear
    • Viral-vector-mediated gene transfer

    ASJC Scopus subject areas

    • Neuroscience(all)

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