Resting heart rate and risk of sudden cardiac death in the general population: Influence of left ventricular systolic dysfunction and heart rate-modulating drugs

Carmen Teodorescu, Kyndaron Reinier, Audrey Uy-Evanado, Karen Gunson, Jonathan Jui, Sumeet S. Chugh

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background Higher levels of resting heart rate (HR) have been associated with sudden cardiac death (SCD) but mechanisms are poorly understood. We hypothesized that severe left ventricular systolic dysfunction (LVSD) and HR-modulating drugs explain the HR-SCD relationship. Objective To evaluate the relationship between HR, severe LVSD, HR-modulating drugs, and SCD in the community by using a case-control approach. Methods From the ongoing Oregon Sudden Unexpected Death Study, SCD cases (n = 378) aged ≥35 years and with electrocardiogram-documented resting HR were compared to 378 age- and gender-matched control subjects with coronary artery disease (mean age 68 ± 13 years; 69% man). Associations with SCD were assessed by using multivariable logistic regression. Results Mean resting HR was significantly higher among SCD cases compared to controls (7.5 beats/min difference; P <.0001). HR was a significant determinant of SCD after adjustment for significant comorbidities and medications (odds ratio for 10 beats/min increase 1.26; 95% confidence interval 1.14-1.38; P <.0001). After considering LVSD, resting HR was slightly attenuated but remained significantly associated with SCD (P =.005). In addition to diabetes and digoxin as well as pulmonary and renal disease, LVSD was also independently associated with SCD (odds ratio 1.79; 95% confidence interval 1.11-2.87; P =.02). Conclusions Contrary to expectations, the significant relationship between increased resting HR and SCD persisted even after adjustment for LVSD and HR-modulating drugs. These findings suggest a potential role for additional novel interventions/therapies that modulate autonomic tone.

Original languageEnglish (US)
Pages (from-to)1153-1158
Number of pages6
JournalHeart Rhythm
Volume10
Issue number8
DOIs
StatePublished - Aug 1 2013

Keywords

  • Beta-blockers
  • Cardiac arrest
  • Case-control study
  • Heart failure
  • Medications
  • Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Resting heart rate and risk of sudden cardiac death in the general population: Influence of left ventricular systolic dysfunction and heart rate-modulating drugs'. Together they form a unique fingerprint.

  • Cite this