Resting heart rate and risk of sudden cardiac death in the general population

Influence of left ventricular systolic dysfunction and heart rate-modulating drugs

Carmen Teodorescu, Kyndaron Reinier, Audrey Uy-Evanado, Karen Gunson, Jonathan Jui, Sumeet S. Chugh

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background Higher levels of resting heart rate (HR) have been associated with sudden cardiac death (SCD) but mechanisms are poorly understood. We hypothesized that severe left ventricular systolic dysfunction (LVSD) and HR-modulating drugs explain the HR-SCD relationship. Objective To evaluate the relationship between HR, severe LVSD, HR-modulating drugs, and SCD in the community by using a case-control approach. Methods From the ongoing Oregon Sudden Unexpected Death Study, SCD cases (n = 378) aged ≥35 years and with electrocardiogram-documented resting HR were compared to 378 age- and gender-matched control subjects with coronary artery disease (mean age 68 ± 13 years; 69% man). Associations with SCD were assessed by using multivariable logistic regression. Results Mean resting HR was significantly higher among SCD cases compared to controls (7.5 beats/min difference; P

Original languageEnglish (US)
Pages (from-to)1153-1158
Number of pages6
JournalHeart Rhythm
Volume10
Issue number8
DOIs
StatePublished - Aug 2013

Fingerprint

Sudden Cardiac Death
Left Ventricular Dysfunction
Heart Rate
Pharmaceutical Preparations
Population
Sudden Death
Coronary Artery Disease
Electrocardiography
Logistic Models

Keywords

  • Beta-blockers
  • Cardiac arrest
  • Case-control study
  • Heart failure
  • Medications
  • Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Resting heart rate and risk of sudden cardiac death in the general population : Influence of left ventricular systolic dysfunction and heart rate-modulating drugs. / Teodorescu, Carmen; Reinier, Kyndaron; Uy-Evanado, Audrey; Gunson, Karen; Jui, Jonathan; Chugh, Sumeet S.

In: Heart Rhythm, Vol. 10, No. 8, 08.2013, p. 1153-1158.

Research output: Contribution to journalArticle

Teodorescu, Carmen ; Reinier, Kyndaron ; Uy-Evanado, Audrey ; Gunson, Karen ; Jui, Jonathan ; Chugh, Sumeet S. / Resting heart rate and risk of sudden cardiac death in the general population : Influence of left ventricular systolic dysfunction and heart rate-modulating drugs. In: Heart Rhythm. 2013 ; Vol. 10, No. 8. pp. 1153-1158.
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