@article{4591877151424f219f0994dbb7bfc493,
title = "REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons",
abstract = "Expression of the type II voltage-dependent sodium channel gene is restricted to neurons by a silencer element active in nonneuronal cells. We have cloned cDNA coding for a transcription factor (REST) that binds to this silencer element. Expression of a recombinant REST protein confers the ability to silence type II reporter genes in neuronal cell types lacking the native REST protein, whereas expression of a dominant negative form of REST in nonneuronal cells relieves silencing mediated by the native protein. REST transcripts in developing mouse embryos are detected ubiquitously outside of the nervous system. We propose that expression of the type II sodium channel gene in neurons reflects a default pathway that is blocked in nonneuronal cells by the presence of REST.",
author = "Chong, {Jayhong A.} and Jos{\'e} Tapia-Ramirez and Sandra Kim and Toledo-Aral, {Juan J.} and Yingcong Zheng and Boutros, {Michael C.} and Altshuller, {Yelena M.} and Frohman, {Michael A.} and Kraner, {Susan D.} and Gail Mandel",
note = "Funding Information: The authors are indebted to the laboratories of Drs. S. Halegoua, R. Sternglanz, and S. Fields for providing reagents, expertise, and encouragement throughout the course of the work. The authors thank D. Kennedy, C. Zindl, J. Wells, D. Colflesh, and Dr. S. Tsirka for technical assistance in experiments and Drs. P. Brehm and R. Goodman for valuable discussions and critical reading of the manuscript. The work was supported by grants from the National Institutes of Health (NIH) and National Science Foundation to G. M., by an NIH grant to M. A. F., and by a postdoctoral fellowship to J. J. T.-A. from the Spanish Ministerio de Educaci6n y Ciencia. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",
year = "1995",
month = mar,
day = "24",
doi = "10.1016/0092-8674(95)90298-8",
language = "English (US)",
volume = "80",
pages = "949--957",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",
}