Responses of peripheral blood flow to acute hypoxia and hyperoxia as measured by optical microangiography

Jia Yali, Peng Li, Suzan Dziennis, Ruikang K. Wang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Oxygen availability is regarded as a critical factor to metabolically regulate systemic blood flow. There is a debate as to how peripheral blood flow (PBF) is affected and modulated during hypoxia and hyperoxia; however in vivo evaluating of functional PBF under oxygen-related physiological perturbation remains challenging. Microscopic observation, the current frequently used imaging modality for PBF characterization often involves the use of exogenous contrast agents, which would inevitably perturb the intrinsic physiologic responses of microcirculation being investigated. In this paper, optical micro-angiography (OMAG) was employed that uses intrinsic optical scattering signals backscattered from blood flows for imaging PBF in skeletal muscle challenged by the alteration of oxygen concentration. By utilizing optical reflectance signals, we demonstrated that OMAG is able to show the response of hemodynamic activities upon acute hypoxia and hyperoxia, including the modulation of macrovascular caliber, microvascular density, and flux regulation within different sized vessels within skeletal muscle in mice in vivo. Our results suggest that OMAG is a promising tool for in vivo monitoring of functional macro- or micro-vascular responses within peripheral vascular beds.

Original languageEnglish (US)
Article numbere26802
JournalPLoS One
Volume6
Issue number10
DOIs
StatePublished - Oct 25 2011
Externally publishedYes

Fingerprint

hyperoxia
Hyperoxia
blood flow
hypoxia
Blood
Angiography
blood vessels
Blood Vessels
Oxygen
oxygen
Muscle
skeletal muscle
Skeletal Muscle
image analysis
Microcirculation
Imaging techniques
Computer peripheral equipment
Hemodynamics
hemodynamics
Contrast Media

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Responses of peripheral blood flow to acute hypoxia and hyperoxia as measured by optical microangiography. / Yali, Jia; Li, Peng; Dziennis, Suzan; Wang, Ruikang K.

In: PLoS One, Vol. 6, No. 10, e26802, 25.10.2011.

Research output: Contribution to journalArticle

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