Resistance training reduces disability in prostate cancer survivors on androgen deprivation therapy: Evidence from a randomized controlled trial

Kerri Winters-Stone, Jessica C. Dobek, Jill Bennett, Nathan Dieckmann, Gianni F. Maddalozzo, Christopher Ryan, Tomasz (Tom) Beer

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Conclusions: One year of resistance training improved muscle strength in androgen-deprived PCS. Strengthening muscles using functional movement patterns may be an important feature of exercise programs designed to improve perceptions of physical function and disability. Findings from this study contribute to the mounting evidence that exercise should become a routine part of clinical care in older men with advanced prostate cancer.

Objectives: To investigate whether functionally based resistance exercise could improve strength, physical function, and disability among prostate cancer survivors (PCS) on androgen deprivation therapy (ADT); and to explore potential mediators of changes in outcomes from exercise.

Design: Randomized controlled trial.

Setting: Academic medical center.

Participants: PCS (N=51; mean age, 70.2y) on ADT. Intervention PCS were randomized to moderate to vigorous intensity resistance training or stretching (placebo control) for 1 year.

Main Outcome Measures: Maximal leg press and bench press strength, objective and self-reported physical function, and self-reported disability. Hierarchical linear modeling was used to test for significant group × time differences adjusting for covariates.

Results: Retention in the study was 84%, and median attendance to supervised classes was 84% in the resistance group. No study-related injuries occurred. Maximal leg strength (P=.032) and bench press strength (P=.027) were improved after 1 year of resistance training, whereas little change occurred from stretching. Self-reported physical function improved with resistance training, whereas decreases occurred from stretching (P=.016). Disability lessened more with resistance training than stretching (P=.018). One-year change in leg press strength mediated the relation between groups (resistance or stretching) and 1-year change in self-reported disability (P

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalArchives of Physical Medicine and Rehabilitation
Volume96
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Resistance Training
Androgens
Survivors
Prostatic Neoplasms
Randomized Controlled Trials
Exercise
Leg
Therapeutics
Muscle Strength
Placebos
Outcome Assessment (Health Care)
Muscles
Wounds and Injuries

Keywords

  • Activities of daily living
  • Exercise
  • Men
  • Muscle strength
  • Neoplasm
  • Rehabilitation
  • Strength training

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Medicine(all)

Cite this

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title = "Resistance training reduces disability in prostate cancer survivors on androgen deprivation therapy: Evidence from a randomized controlled trial",
abstract = "Conclusions: One year of resistance training improved muscle strength in androgen-deprived PCS. Strengthening muscles using functional movement patterns may be an important feature of exercise programs designed to improve perceptions of physical function and disability. Findings from this study contribute to the mounting evidence that exercise should become a routine part of clinical care in older men with advanced prostate cancer.Objectives: To investigate whether functionally based resistance exercise could improve strength, physical function, and disability among prostate cancer survivors (PCS) on androgen deprivation therapy (ADT); and to explore potential mediators of changes in outcomes from exercise.Design: Randomized controlled trial.Setting: Academic medical center.Participants: PCS (N=51; mean age, 70.2y) on ADT. Intervention PCS were randomized to moderate to vigorous intensity resistance training or stretching (placebo control) for 1 year.Main Outcome Measures: Maximal leg press and bench press strength, objective and self-reported physical function, and self-reported disability. Hierarchical linear modeling was used to test for significant group × time differences adjusting for covariates.Results: Retention in the study was 84{\%}, and median attendance to supervised classes was 84{\%} in the resistance group. No study-related injuries occurred. Maximal leg strength (P=.032) and bench press strength (P=.027) were improved after 1 year of resistance training, whereas little change occurred from stretching. Self-reported physical function improved with resistance training, whereas decreases occurred from stretching (P=.016). Disability lessened more with resistance training than stretching (P=.018). One-year change in leg press strength mediated the relation between groups (resistance or stretching) and 1-year change in self-reported disability (P",
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T2 - Evidence from a randomized controlled trial

AU - Winters-Stone, Kerri

AU - Dobek, Jessica C.

AU - Bennett, Jill

AU - Dieckmann, Nathan

AU - Maddalozzo, Gianni F.

AU - Ryan, Christopher

AU - Beer, Tomasz (Tom)

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N2 - Conclusions: One year of resistance training improved muscle strength in androgen-deprived PCS. Strengthening muscles using functional movement patterns may be an important feature of exercise programs designed to improve perceptions of physical function and disability. Findings from this study contribute to the mounting evidence that exercise should become a routine part of clinical care in older men with advanced prostate cancer.Objectives: To investigate whether functionally based resistance exercise could improve strength, physical function, and disability among prostate cancer survivors (PCS) on androgen deprivation therapy (ADT); and to explore potential mediators of changes in outcomes from exercise.Design: Randomized controlled trial.Setting: Academic medical center.Participants: PCS (N=51; mean age, 70.2y) on ADT. Intervention PCS were randomized to moderate to vigorous intensity resistance training or stretching (placebo control) for 1 year.Main Outcome Measures: Maximal leg press and bench press strength, objective and self-reported physical function, and self-reported disability. Hierarchical linear modeling was used to test for significant group × time differences adjusting for covariates.Results: Retention in the study was 84%, and median attendance to supervised classes was 84% in the resistance group. No study-related injuries occurred. Maximal leg strength (P=.032) and bench press strength (P=.027) were improved after 1 year of resistance training, whereas little change occurred from stretching. Self-reported physical function improved with resistance training, whereas decreases occurred from stretching (P=.016). Disability lessened more with resistance training than stretching (P=.018). One-year change in leg press strength mediated the relation between groups (resistance or stretching) and 1-year change in self-reported disability (P

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