Repolarization lability measured by spatial TT' angle

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    4 Citations (Scopus)

    Abstract

    Aims: Increased T peaks cloud volume is associated with increased risk of ventricular arrhythmias (VA) in cardiomyopathy (CM) patients. T peaks cloud volume is formed, as a result, of (1) the angle between consecutive T-vectors and (2) temporal variability in T-vector amplitude. This study compares association of these two factors with VA. Methods: Baseline orthogonal ECGs were recorded during 5 min at rest in 414 patients with structural heart disease [mean age 59.4±12.0; 68% whites; 73% men; 45% non-ischemic CM] before implantation of implantable cardioverter-defibrillator (ICD) for primary prevention of sudden cardiac death. The spatial TT' angle between consecutive spatial T vectors was calculated using the definition of the inner product. Results: During a median 14 months of follow-up, 61 patients experienced sustained VA with appropriate ICD therapies. In a multivariable Cox regression model after adjustment for age, sex, race, spatial TT' angle was associated with VA (HR 1.03; 95%CI 1.0-1.05; P=0.034). Interaction with CM type was found: TT' angle was strongly associated with polymorphic VT/VF in non-ischemic CM (HR 1.04; 95%CI 1.0-1.05; P=0.033). Conclusion: Increased spatial TT' angle is associated with increased risk of VA.

    Original languageEnglish (US)
    Title of host publicationComputing in Cardiology
    PublisherIEEE Computer Society
    Pages181-184
    Number of pages4
    Volume41
    EditionJanuary
    StatePublished - 2014
    Event41st Computing in Cardiology Conference, CinC 2014 - Cambridge, United States
    Duration: Sep 7 2014Sep 10 2014

    Other

    Other41st Computing in Cardiology Conference, CinC 2014
    CountryUnited States
    CityCambridge
    Period9/7/149/10/14

    Fingerprint

    Implantable cardioverter defibrillators
    Cardiac Arrhythmias
    Cardiomyopathies
    Implantable Defibrillators
    Electrocardiography
    Sudden Cardiac Death
    Primary Prevention
    Proportional Hazards Models
    Heart Diseases

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Computer Science(all)

    Cite this

    Tereshchenko, L. (2014). Repolarization lability measured by spatial TT' angle. In Computing in Cardiology (January ed., Vol. 41, pp. 181-184). [7043009] IEEE Computer Society.

    Repolarization lability measured by spatial TT' angle. / Tereshchenko, Larisa.

    Computing in Cardiology. Vol. 41 January. ed. IEEE Computer Society, 2014. p. 181-184 7043009.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Tereshchenko, L 2014, Repolarization lability measured by spatial TT' angle. in Computing in Cardiology. January edn, vol. 41, 7043009, IEEE Computer Society, pp. 181-184, 41st Computing in Cardiology Conference, CinC 2014, Cambridge, United States, 9/7/14.
    Tereshchenko L. Repolarization lability measured by spatial TT' angle. In Computing in Cardiology. January ed. Vol. 41. IEEE Computer Society. 2014. p. 181-184. 7043009
    Tereshchenko, Larisa. / Repolarization lability measured by spatial TT' angle. Computing in Cardiology. Vol. 41 January. ed. IEEE Computer Society, 2014. pp. 181-184
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    abstract = "Aims: Increased T peaks cloud volume is associated with increased risk of ventricular arrhythmias (VA) in cardiomyopathy (CM) patients. T peaks cloud volume is formed, as a result, of (1) the angle between consecutive T-vectors and (2) temporal variability in T-vector amplitude. This study compares association of these two factors with VA. Methods: Baseline orthogonal ECGs were recorded during 5 min at rest in 414 patients with structural heart disease [mean age 59.4±12.0; 68{\%} whites; 73{\%} men; 45{\%} non-ischemic CM] before implantation of implantable cardioverter-defibrillator (ICD) for primary prevention of sudden cardiac death. The spatial TT' angle between consecutive spatial T vectors was calculated using the definition of the inner product. Results: During a median 14 months of follow-up, 61 patients experienced sustained VA with appropriate ICD therapies. In a multivariable Cox regression model after adjustment for age, sex, race, spatial TT' angle was associated with VA (HR 1.03; 95{\%}CI 1.0-1.05; P=0.034). Interaction with CM type was found: TT' angle was strongly associated with polymorphic VT/VF in non-ischemic CM (HR 1.04; 95{\%}CI 1.0-1.05; P=0.033). Conclusion: Increased spatial TT' angle is associated with increased risk of VA.",
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