TY - JOUR
T1 - Replacement of the proximal aorta and aortic valve using a composite bileaflet prosthesis and gelatin-impregnated polyester graft (Carbo-Seal)
T2 - Early results in 143 patients
AU - Langley, S. M.
AU - Rooney, S. J.
AU - Dalrymple-Hay, M. J.R.
AU - Spencer, J. M.F.
AU - Lewis, M. E.
AU - Pagano, D.
AU - Asif, M.
AU - Goddard, J. R.
AU - Tsang, V. T.
AU - Lamb, R. K.
AU - Monro, J. L.
AU - Livesey, S. A.
AU - Bonser, R. S.
PY - 1999
Y1 - 1999
N2 - Objective: We report the combined early results from two centers in the United Kingdom using a composite conduit consisting of a bileaflet mechanical valve incorporated into a gelatin-impregnated, ultra-low porosity, woven polyester graft (Carbo-Seal; Sulzer Carbomedics, Inc, Austin, Tex). Methods: Between August 1992 and March 1997, 143 patients underwent aortic root replacement with the Carbo-Seal composite prosthesis. The indication for surgery was acute type A dissection in 31 (22%), chronic type A dissection in 9 (6%), ascending aortic aneurysm without dissection in 100 (70%), and false aneurysm of the ascending aorta in 3 (2%). Twenty-seven patients (19%) had undergone previous sternotomy, and 40 (28%) were seen as emergencies. Concomitant procedures were performed in 38 (27%), including 18 aortic arch or hemiarch replacements. Total follow-up is 270 patient-years. Follow-up is 100% complete. Results: The early (30-day) mortality was 7% (10 patients). Permanent neurologic events occurred in 2%. At a mean follow-up of 23 months, 94 % of survivors were in New York Heart Association functional class I. Freedom from reoperation was 97.2% ± 1.6% (1 standard error [1 SE]) at 12 months and 95.7% ± 2.2% at 48 months. Including early mortality, survival was 90.1% ± 2.6% at 12 months and 83.1% ± 3.5% at 48 months. Conclusions: Aortic root replacement with use of the Carbo-Seal prosthesis can be undertaken with a relatively low early mortality and morbidity. A low reoperation rate and high intermediate-term survival can be expected, but continued follow-up is needed to determine the long-term efficacy of this prosthesis.
AB - Objective: We report the combined early results from two centers in the United Kingdom using a composite conduit consisting of a bileaflet mechanical valve incorporated into a gelatin-impregnated, ultra-low porosity, woven polyester graft (Carbo-Seal; Sulzer Carbomedics, Inc, Austin, Tex). Methods: Between August 1992 and March 1997, 143 patients underwent aortic root replacement with the Carbo-Seal composite prosthesis. The indication for surgery was acute type A dissection in 31 (22%), chronic type A dissection in 9 (6%), ascending aortic aneurysm without dissection in 100 (70%), and false aneurysm of the ascending aorta in 3 (2%). Twenty-seven patients (19%) had undergone previous sternotomy, and 40 (28%) were seen as emergencies. Concomitant procedures were performed in 38 (27%), including 18 aortic arch or hemiarch replacements. Total follow-up is 270 patient-years. Follow-up is 100% complete. Results: The early (30-day) mortality was 7% (10 patients). Permanent neurologic events occurred in 2%. At a mean follow-up of 23 months, 94 % of survivors were in New York Heart Association functional class I. Freedom from reoperation was 97.2% ± 1.6% (1 standard error [1 SE]) at 12 months and 95.7% ± 2.2% at 48 months. Including early mortality, survival was 90.1% ± 2.6% at 12 months and 83.1% ± 3.5% at 48 months. Conclusions: Aortic root replacement with use of the Carbo-Seal prosthesis can be undertaken with a relatively low early mortality and morbidity. A low reoperation rate and high intermediate-term survival can be expected, but continued follow-up is needed to determine the long-term efficacy of this prosthesis.
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U2 - 10.1016/S0022-5223(99)70095-4
DO - 10.1016/S0022-5223(99)70095-4
M3 - Article
C2 - 10595972
AN - SCOPUS:0032700395
SN - 0022-5223
VL - 118
SP - 1014
EP - 1020
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
IS - 6
ER -