Repeated electroconvulsive shock: Effect on sodium dependency and regional distribution of opioid-binding sites

R. J. Hitzemann, B. A. Hitzemann, S. Blatt, J. L. Meyerhoff, F. C. Tortella, J. R. Kenner, G. L. Belenky, J. W. Holaday

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Abstract

The effects of single and repeated electrocnvulsive shock (ECS) on the binding of [3H]diprenorphine to rat brain membranes was studied. Repeated but not single ECS significantly incresed th B(max) of [3H]dirpenorphine binding when measured in the absence but not in the presence of NaCl. On a regional basis the effect of ECS was greatest in the olfactory bulb, nucleus accumbens, and striatum. More modest increases were found in the hippocampus, amygdala, septum, hypothalamus, and pyriform cortex. No significant effect was found in the brainstem and frontal cortex. Although the regional rank order of receptor increase does not match the receptor distribution of brain enkephalins, the receptor increase does parallel the regional increases in brain enkephalins following ECS.

Original languageEnglish (US)
Pages (from-to)562-566
Number of pages5
JournalMolecular pharmacology
Volume31
Issue number5
StatePublished - Oct 6 1987

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Hitzemann, R. J., Hitzemann, B. A., Blatt, S., Meyerhoff, J. L., Tortella, F. C., Kenner, J. R., Belenky, G. L., & Holaday, J. W. (1987). Repeated electroconvulsive shock: Effect on sodium dependency and regional distribution of opioid-binding sites. Molecular pharmacology, 31(5), 562-566.