Repeated electroconvulsive shock: Effect on sodium dependency and regional distribution of opioid-binding sites

Robert Hitzemann, B. A. Hitzemann, S. Blatt, J. L. Meyerhoff, F. C. Tortella, J. R. Kenner, G. L. Belenky, J. W. Holaday

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effects of single and repeated electrocnvulsive shock (ECS) on the binding of [3H]diprenorphine to rat brain membranes was studied. Repeated but not single ECS significantly incresed th B(max) of [3H]dirpenorphine binding when measured in the absence but not in the presence of NaCl. On a regional basis the effect of ECS was greatest in the olfactory bulb, nucleus accumbens, and striatum. More modest increases were found in the hippocampus, amygdala, septum, hypothalamus, and pyriform cortex. No significant effect was found in the brainstem and frontal cortex. Although the regional rank order of receptor increase does not match the receptor distribution of brain enkephalins, the receptor increase does parallel the regional increases in brain enkephalins following ECS.

Original languageEnglish (US)
Pages (from-to)562-566
Number of pages5
JournalMolecular Pharmacology
Volume31
Issue number5
StatePublished - 1987
Externally publishedYes

Fingerprint

Electroshock
Opioid Analgesics
Shock
Sodium
Binding Sites
Brain
Diprenorphine
Enkephalins
Olfactory Bulb
Nucleus Accumbens
Opioid Receptors
Frontal Lobe
Amygdala
Hypothalamus
Brain Stem
Hippocampus
Membranes
Dependency (Psychology)

ASJC Scopus subject areas

  • Pharmacology

Cite this

Hitzemann, R., Hitzemann, B. A., Blatt, S., Meyerhoff, J. L., Tortella, F. C., Kenner, J. R., ... Holaday, J. W. (1987). Repeated electroconvulsive shock: Effect on sodium dependency and regional distribution of opioid-binding sites. Molecular Pharmacology, 31(5), 562-566.

Repeated electroconvulsive shock : Effect on sodium dependency and regional distribution of opioid-binding sites. / Hitzemann, Robert; Hitzemann, B. A.; Blatt, S.; Meyerhoff, J. L.; Tortella, F. C.; Kenner, J. R.; Belenky, G. L.; Holaday, J. W.

In: Molecular Pharmacology, Vol. 31, No. 5, 1987, p. 562-566.

Research output: Contribution to journalArticle

Hitzemann, R, Hitzemann, BA, Blatt, S, Meyerhoff, JL, Tortella, FC, Kenner, JR, Belenky, GL & Holaday, JW 1987, 'Repeated electroconvulsive shock: Effect on sodium dependency and regional distribution of opioid-binding sites', Molecular Pharmacology, vol. 31, no. 5, pp. 562-566.
Hitzemann, Robert ; Hitzemann, B. A. ; Blatt, S. ; Meyerhoff, J. L. ; Tortella, F. C. ; Kenner, J. R. ; Belenky, G. L. ; Holaday, J. W. / Repeated electroconvulsive shock : Effect on sodium dependency and regional distribution of opioid-binding sites. In: Molecular Pharmacology. 1987 ; Vol. 31, No. 5. pp. 562-566.
@article{1950b3713a00468dba5381fc84cc03bc,
title = "Repeated electroconvulsive shock: Effect on sodium dependency and regional distribution of opioid-binding sites",
abstract = "The effects of single and repeated electrocnvulsive shock (ECS) on the binding of [3H]diprenorphine to rat brain membranes was studied. Repeated but not single ECS significantly incresed th B(max) of [3H]dirpenorphine binding when measured in the absence but not in the presence of NaCl. On a regional basis the effect of ECS was greatest in the olfactory bulb, nucleus accumbens, and striatum. More modest increases were found in the hippocampus, amygdala, septum, hypothalamus, and pyriform cortex. No significant effect was found in the brainstem and frontal cortex. Although the regional rank order of receptor increase does not match the receptor distribution of brain enkephalins, the receptor increase does parallel the regional increases in brain enkephalins following ECS.",
author = "Robert Hitzemann and Hitzemann, {B. A.} and S. Blatt and Meyerhoff, {J. L.} and Tortella, {F. C.} and Kenner, {J. R.} and Belenky, {G. L.} and Holaday, {J. W.}",
year = "1987",
language = "English (US)",
volume = "31",
pages = "562--566",
journal = "Molecular Pharmacology",
issn = "0026-895X",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "5",

}

TY - JOUR

T1 - Repeated electroconvulsive shock

T2 - Effect on sodium dependency and regional distribution of opioid-binding sites

AU - Hitzemann, Robert

AU - Hitzemann, B. A.

AU - Blatt, S.

AU - Meyerhoff, J. L.

AU - Tortella, F. C.

AU - Kenner, J. R.

AU - Belenky, G. L.

AU - Holaday, J. W.

PY - 1987

Y1 - 1987

N2 - The effects of single and repeated electrocnvulsive shock (ECS) on the binding of [3H]diprenorphine to rat brain membranes was studied. Repeated but not single ECS significantly incresed th B(max) of [3H]dirpenorphine binding when measured in the absence but not in the presence of NaCl. On a regional basis the effect of ECS was greatest in the olfactory bulb, nucleus accumbens, and striatum. More modest increases were found in the hippocampus, amygdala, septum, hypothalamus, and pyriform cortex. No significant effect was found in the brainstem and frontal cortex. Although the regional rank order of receptor increase does not match the receptor distribution of brain enkephalins, the receptor increase does parallel the regional increases in brain enkephalins following ECS.

AB - The effects of single and repeated electrocnvulsive shock (ECS) on the binding of [3H]diprenorphine to rat brain membranes was studied. Repeated but not single ECS significantly incresed th B(max) of [3H]dirpenorphine binding when measured in the absence but not in the presence of NaCl. On a regional basis the effect of ECS was greatest in the olfactory bulb, nucleus accumbens, and striatum. More modest increases were found in the hippocampus, amygdala, septum, hypothalamus, and pyriform cortex. No significant effect was found in the brainstem and frontal cortex. Although the regional rank order of receptor increase does not match the receptor distribution of brain enkephalins, the receptor increase does parallel the regional increases in brain enkephalins following ECS.

UR - http://www.scopus.com/inward/record.url?scp=0023279641&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023279641&partnerID=8YFLogxK

M3 - Article

C2 - 3033470

AN - SCOPUS:0023279641

VL - 31

SP - 562

EP - 566

JO - Molecular Pharmacology

JF - Molecular Pharmacology

SN - 0026-895X

IS - 5

ER -